Application | Comment | Organism |
---|---|---|
medicine | the BLS scaffold is assessed for in plants for recombinant vaccine development by N-terminally fusing BLS to bovine rotavirus VP8d and expressing the resulting fusion (BLS-VP8d) in Nicotiana tabacum chloroplasts. BLS-VP8d remains soluble and stable during all stages of plant development and even in lyophilized leaves stored at room temperature | Brucella sp. |
Cloned (Comment) | Organism |
---|---|
construction of a fusion protein with enzyme BLS and inner core domain (VP8d) of VP8 spike protein from bovine rotavirus, subcloning in Escherichia coli, expression of the BLS-VP8d fusion protein in Nicotiana tabacum cv. Petit Havana leaf chloroplasts to evaluate the possible use of this antigen for vaccine development | Brucella sp. |
Protein Variants | Comment | Organism |
---|---|---|
additional information | chloroplast transformation vector and analysis of transgene integration. The BLS scaffold is assessed for in plants for recombinant vaccine development by N-terminally fusing BLS to bovine rotavirus VP8d and expressing the resulting fusion (BLS-VP8d) in Nicotiana tabacum chloroplasts. BLS-VP8d remains soluble and stable during all stages of plant development and even in lyophilized leaves stored at room temperature | Brucella sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brucella sp. | P61711 | - |
- |
Brucella sp. 9-941 | P61711 | - |
- |
Subunits | Comment | Organism |
---|---|---|
decamer | - |
Brucella sp. |
Synonyms | Comment | Organism |
---|---|---|
BLS | - |
Brucella sp. |
lumazine synthase | - |
Brucella sp. |
General Information | Comment | Organism |
---|---|---|
physiological function | lumazine synthase from Brucella spp.is a highly immunogenic decameric protein which can accommodate foreign polypeptides or protein domains fused to its N-termini, markedly increasing their immunogenicity | Brucella sp. |