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Literature summary for 2.5.1.78 extracted from

  • Bonomi, H.; Marchesini, M.; Klinke, S.; Ugalde, J.; Zylberman, V.; Ugalde, R.; Comerci, D.; Goldbaum, F.
    An atypical riboflavin pathway is essential for Brucella abortus virulence (2010), PLoS ONE, 5, e9435.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
W22A single amino acid mutation located in the active site of the endogenous RibH2. Mutant lacks enzymatic activity but its stability and structure are unaltered Brucella abortus

Organism

Organism UniProt Comment Textmining
Brucella abortus P61711 isoform RibH2
-
Brucella abortus Q57DY1 isoform RibH1
-

Synonyms

Synonyms Comment Organism
luminazine synthase
-
Brucella abortus
ribH1
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Brucella abortus
RibH2
-
Brucella abortus

General Information

General Information Comment Organism
physiological function disruption mutants of either isform RibH1 or RibH2 obtained without any major difficulty, are not auxotrophic for riboflavin and grow at wild-type rates in both rich and minimal media. A double mutant lacking both RibH1 and RibH2 activity is not viable Brucella abortus
physiological function disruption mutants of either isform RibH1 or RibH2 obtained without any major difficulty, are not auxotrophic for riboflavin and grow at wild-type rates in both rich and minimal media. A double mutant lacking both RibH1 and RibH2 activity is not viable. For virulence, at least one isoform must be present for Brucella abortus survival and RibH2 and not RibH1 is essential for intracellular survival due to its luminazine synthase activity in vivo. Brucella abortus