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Literature summary for 2.5.1.78 extracted from

  • Talukdar, A.; Illarionov, B.; Bacher, A.; Fischer, M.; Cushman, M.
    Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase (2007), J. Org. Chem., 72, 7167-7175.
    View publication on PubMed
Search for more literature for 2.5.1.78

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular modeling of enzyme with inhibitor 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride inhibition of both lumazine synthase and riboflavin synthase Bacillus subtilis
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride inhibition of both lumazine synthase and riboflavin synthase Mycobacterium tuberculosis
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride inhibition of both lumazine synthase and riboflavin synthase Schizosaccharomyces pombe
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione inhibition of both lumazine synthase and riboflavin synthase Bacillus subtilis
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione inhibition of both lumazine synthase and riboflavin synthase Mycobacterium tuberculosis
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione inhibition of both lumazine synthase and riboflavin synthase Schizosaccharomyces pombe

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Mycobacterium tuberculosis
-
-
-
Schizosaccharomyces pombe
-
-
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
27
-
 assay at Bacillus subtilis
27
-
 assay at Schizosaccharomyces pombe
37
-
 assay at Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Bacillus subtilis
7
-
 assay at Schizosaccharomyces pombe
7
-
 assay at Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00016
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Schizosaccharomyces pombe
0.002
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Schizosaccharomyces pombe
0.0026
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Bacillus subtilis
0.011
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Mycobacterium tuberculosis
0.026
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Bacillus subtilis
0.031
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Mycobacterium tuberculosis