Literature summary for 2.5.1.74 extracted from

Debnath, J.; Siricilla, S.; Wan, B.; Crick, D.C.; Lenaerts, A.J.; Franzblau, S.G.; Kurosu, M.
Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis (2012), J. Med. Chem., 55, 3739-3755.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(R)-1-(4-((3-((4-chlorophenyl)(methoxyimino)methyl)phenoxy)-methyl)piperidin-1-yl)octan-2-yl carbamate	MIC value for Mycobacterium tuberculosis 0.0023 mg/ml	Mycobacterium tuberculosis
(R)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)-octan-2-yl carbamate	MIC value for Mycobacterium tuberculosis 0.0023 mg/ml	Mycobacterium tuberculosis
(S)-(2-chloro-4-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)-phenyl)(4-chlorophenyl)methanone	MIC value for Mycobacterium tuberculosis 0.0015 mg/ml	Mycobacterium tuberculosis
(S)-1-(4-((3-chloro-4-((4-chlorophenyl)(methoxyimino)methyl)-phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate	MIC value for Mycobacterium tuberculosis 0.0015 mg/ml	Mycobacterium tuberculosis
(S)-1-(4-((3-chloro-4-(4-chlorobenzoyl)phenoxy)methyl)-piperidin-1-yl)octan-2-yl carbamate	MIC value for Mycobacterium tuberculosis 0.0015 mg/ml	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0012	-	pH 8.0, 37°C	Mycobacterium tuberculosis	(R)-1-(4-((3-((4-chlorophenyl)(methoxyimino)methyl)phenoxy)-methyl)piperidin-1-yl)octan-2-yl carbamate
0.0015	-	pH 8.0, 37°C	Mycobacterium tuberculosis	(R)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)-octan-2-yl carbamate
0.0015	-	pH 8.0, 37°C	Mycobacterium tuberculosis	(S)-1-(4-((3-chloro-4-(4-chlorobenzoyl)phenoxy)methyl)-piperidin-1-yl)octan-2-yl carbamate
0.0015	-	pH 8.0, 37°C	Mycobacterium tuberculosis	(S)-1-(4-((3-chloro-4-((4-chlorophenyl)(methoxyimino)methyl)-phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate
0.0035	-	pH 8.0, 37°C	Mycobacterium tuberculosis	(S)-(2-chloro-4-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)-phenyl)(4-chlorophenyl)methanone

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Release 2023.1 (January 2023)