Literature summary for 2.5.1.72 extracted from

Fenwick, M.K.; Ealick, S.E.
Crystal structures of the iron-sulfur cluster-dependent quinolinate synthase in complex with dihydroxyacetone phosphate, iminoaspartate analogues, and quinolinate (2016), Biochemistry, 55, 4135-4139 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structures of NadA in complex with dihydroxyacetone phosphate, iminoaspartate analogues, and quinolinate. Dihydroxyacetone phosphate adopts a nearly planar conformation and chelates the [4Fe-4S] cluster via its keto and hydroxyl groups. The cluster may act as a Lewis acid in enediolate formation, like zinc in class II aldolases	Pyrococcus horikoshii

Organism

Organism	UniProt	Comment	Textmining
Pyrococcus horikoshii	O57767	-	-
Pyrococcus horikoshii DSM 12428	O57767	-	-

Synonyms

Synonyms	Comment	Organism
NadA	-	Pyrococcus horikoshii

Cofactor

Cofactor	Comment	Organism	Structure
[4Fe-4S]-center	substrate dihydroxyacetone phosphate chelates the cluster	Pyrococcus horikoshii

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Release 2023.1 (January 2023)