Literature summary for 2.5.1.72 extracted from

Chan, A.; Clemancey, M.; Mouesca, J.M.; Amara, P.; Hamelin, O.; Latour, J.M.; Ollagnier de Choudens, S.
Studies of inhibitor binding to the [4Fe-4S] cluster of quinolinate synthase (2012), Angew. Chem. Int. Ed. Engl., 51, 7711-7714.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4,5-dithiohydroxyphthalic acid	structural analogue of the 5-hydroxy-4,5-dihydropyridine-2,3-dicarboxylic acid intermediate. Compound coordinates to the enzyme [4Fe-4S] cluster through a differentiated iron site, thus leading to the inhibition of quinolate formation. Compound is inhibitory in vitro and in vivo	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Synonyms

Synonyms	Comment	Organism
NadA	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
4Fe-4S-center	inhibitor 4,5-dithiohydroxyphthalic acid coordinates to the enzyme [4Fe-4S] cluster through a differentiated iron site	Escherichia coli

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.007	-	pH not specified in the publication, temperature not specified in the publication	Escherichia coli	4,5-dithiohydroxyphthalic acid

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Release 2023.1 (January 2023)