Literature summary for 2.5.1.72 extracted from

Ollagnier-de Choudens, S.; Loiseau, L.; Sanakis, Y.; Barras, F.; Fontecave, M.
Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis (2005), FEBS Lett., 579, 3737-3743.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	protein contains 3-3.5 mol iron and 3-3.5 mol sulfur per mol	Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
39300	-	plus minor amount of monomer. 2 * 40000, SDS-PAGE, 2 * 39300, calculated	Escherichia coli
40000	-	gel filtration, minor amount of protein	Escherichia coli
80000	-	gel filtration, major amount of protein	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Subunits

Subunits	Comment	Organism
dimer	plus minor amount of monomer. 2 * 40000, SDS-PAGE, 2 * 39300, calculated	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
iron-sulfur centre	protein contains 3-3.5 mol iron and 3-3.5 mol sulfur per mol. Majority of the iron is in the form of a [4Fe-4S]2+ cluster. The cluster is absolutely required for activity	Escherichia coli

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Release 2023.1 (January 2023)