Application | Comment | Organism |
---|---|---|
medicine | target for development of antibacterial agents | Chlamydia trachomatis |
Cloned (Comment) | Organism |
---|---|
gene murA, DNA sequence analysis, expression in Escherichia coli under control of the arabinose-inducible, glucose-repressible ara promotor, functional complementation, necessary for viability, of a enzyme-deficient Escherichia coli murA null-mutant, impartment of fosfomycin resistance to the Escherichia coli cell | Chlamydia trachomatis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fosfomycin | resistant to fosfomycin inhibition due to exchange of cysteine for aspartate in the active site | Chlamydia trachomatis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | Chlamydia trachomatis | peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | Chlamydia trachomatis MurA | peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlamydia trachomatis | - |
MurA | - |
Chlamydia trachomatis | - |
gene murA | - |
Chlamydia trachomatis | - |
serovar L2 | - |
Chlamydia trachomatis MurA | - |
MurA | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | exchange of cysteine to aspartate in the active site | Chlamydia trachomatis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Chlamydia trachomatis | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division | Chlamydia trachomatis | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Chlamydia trachomatis MurA | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division | Chlamydia trachomatis MurA | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? |