Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-Bromopyruvate | irreversible, inhibitory effect is increased by UDP-GlcNAc | Enterobacter cloacae | |
fosfomycin | irreversible, active site SH-group is involved | Enterobacter cloacae | |
additional information | no inhibition by pyruvate and fluoropyruvate | Enterobacter cloacae | |
phosphoenol-2-ketovalerate | - |
Enterobacter cloacae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | Enterobacter cloacae | enzyme catalyzes the first committed step in the biosynthesis of bacterial cell wall peptidoglycan | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterobacter cloacae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | active site SH-group | Enterobacter cloacae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with (Z)-phosphoenol-2-oxobutyrate, phosphoenol-3-bromopyruvate and phosphoenol-3-phenylpyruvate | Enterobacter cloacae | ? | - |
? | |
phosphoenol-2-oxobutyrate + UDP-N-acetyl-D-glucosamine | - |
Enterobacter cloacae | phosphate + UDP-N-acetylglucosaminyl-enol-2-oxobutyrate | - |
? | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Enterobacter cloacae | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | i.e. UDP-N-acetyl-D-glucosamine-enolpyruvate | ? | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | enzyme catalyzes the first committed step in the biosynthesis of bacterial cell wall peptidoglycan | Enterobacter cloacae | phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.7 | - |
phosphoenol-2-ketovalerate | - |
Enterobacter cloacae |