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Literature summary for 2.5.1.66 extracted from

  • Liras, P.; Rodriguez-Garcia, A.
    Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics (2000), Appl. Microbiol. Biotechnol., 54, 467-475.
    View publication on PubMed
Search for more literature for 2.5.1.66

Cloned(Commentary)

Cloned (Comment) Organism
cea S gene of the gene cluster for clavulanic acid biosynthesis, genomic organization Streptomyces clavuligerus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde 3-phosphate + L-arginine Streptomyces clavuligerus first enzyme in the clavulanic acid biosynthetic pathway, which is a beta-lactamase inhibitor N2-(2-carboxyethyl)-L-arginine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus
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-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces clavuligerus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + L-arginine first enzyme in the clavulanic acid biosynthetic pathway, which is a beta-lactamase inhibitor Streptomyces clavuligerus N2-(2-carboxyethyl)-L-arginine + phosphate
-
 ?
D-glyceraldehyde 3-phosphate + L-arginine CEA synthetase condensates glyceraldehyde 3-phosphate and arginine forming an N-C bond Streptomyces clavuligerus N2-(2-carboxyethyl)-L-arginine + phosphate
-
 ?
additional information not: pyruvic acid Streptomyces clavuligerus ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP requirement Streptomyces clavuligerus
thiamine diphosphate cofactor, requirement Streptomyces clavuligerus