Literature summary for 2.5.1.63 extracted from

Winkler, M.; Domarkas, J.; Schweiger, L.; OHagan, D.
Fluorinase-coupled base swaps: Synthesis of 18F-5'-Deoxy-5'-fluorouridines (2008), Angew. Chem. Int. Ed. Engl., 47, 10141-10143.

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Application

Application	Comment	Organism
biotechnology	production of radiolabelled nucleosides as tracers for cancer cell uptake studies via positron emission tomography	Streptomyces cattleya

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + fluoride	Streptomyces cattleya	18F-tagged substrate with 3 L-amino acid oxidase to remove the byproduct L-methionine enhancing the production reaction, 37°C, 100 mM Tris-HCl buffer, pH 7.5, up to 4 hours, to produce 18F-tagged product, other enzymes can be added to produce several types of nucleosides	5'-deoxy-5'-fluoroadenosine + L-methionine	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces cattleya	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + fluoride	18F-tagged substrate with 3 L-amino acid oxidase to remove the byproduct L-methionine enhancing the production reaction, 37°C, 100 mM Tris-HCl buffer, pH 7.5, up to 4 hours, to produce 18F-tagged product, other enzymes can be added to produce several types of nucleosides	Streptomyces cattleya	5'-deoxy-5'-fluoroadenosine + L-methionine	-	?

Synonyms

Synonyms	Comment	Organism
fluorinase enzyme	-	Streptomyces cattleya

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Release 2023.1 (January 2023)