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Literature summary for 2.5.1.63 extracted from

  • Deng, H.; Cross, S.M.; McGlinchey, R.P.; Hamilton, J.T.; OHagan, D.
    In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase (2008), Chem. Biol., 15, 1268-1276.
    View publication on PubMed
Search for more literature for 2.5.1.63

Application

Application Comment Organism
biotechnology fluorochemical production (18F-labelled organic compounds) for medicinal chemistry research (positron emission tomography), when enzyme acts together with other enzymes in the fluorometabolite production (purine nucleoside phosphorylase, isomerase, aldolase, enzyme generating fluoroacetaldehyde in a retro-aldol reaction, fluoroacetaldehyde dehydrogenase or pyridoxal phosphate-dependent enzyme) to generate fluoroacetaldehyde and 4-fluorothreonine Streptomyces cattleya

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 Streptomyces cattleya
expression in Escherichia coli BL21(DE3) Streptomyces cattleya

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + fluoride Streptomyces cattleya
-
 5'-deoxy-5'-fluoroadenosine + L-methionine
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces cattleya
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces cattleya

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + fluoride
-
 Streptomyces cattleya 5'-deoxy-5'-fluoroadenosine + L-methionine
-
 ?

Synonyms

Synonyms Comment Organism
5'-fluoro-5'-deoxyadenosine synthase
-
 Streptomyces cattleya
flA
-
 Streptomyces cattleya
flA protein
-
 Streptomyces cattleya
fluorinase
-
 Streptomyces cattleya

General Information

General Information Comment Organism
metabolism first enzyme in the fluorometabolite pathway to produce the mammalian toxin fluoroacetate and the antibiotic 4-fluorothreonine Streptomyces cattleya
physiological function part of 4-fluorothreonine biosynthesis Streptomyces cattleya