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Literature summary for 2.5.1.63 extracted from

  • O'Hagan, D.
    Recent developments on the fluorinase from Streptomyces cattleya (2006), J. Fluor. Chem., 127, 1479-1483.
No PubMed abstract available
Search for more literature for 2.5.1.63

Application

Application Comment Organism
analysis the enzyme is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-59-fluoro-59-deoxyadenosine, [18F]-59-fluoro-59-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography, PET, applications, useful for imaging tumors, monitoring the distribution of drugs and identifying cell and receptor degeneration in the brain Streptomyces cattleya
synthesis the enzyme is used in biotransformation reaction for production of fluorinated compounds, biotransformation protocols for coupled reaction systems, overview Streptomyces cattleya

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptomyces cattleya fluoroacetate and 4-fluorothreonine accumulate in the fermentation media of Streptomyces cattleya at the mM level, when a fluoride source is added to the growth medium ?
-
 ?
S-adenosyl-L-methionine + fluoride Streptomyces cattleya
-
 5'-deoxy-5'-fluoroadenosine + L-methionine
-
 r

Organism

Organism UniProt Comment Textmining
Streptomyces cattleya
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine reaction mechanism, overview Streptomyces cattleya
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyadenosyl-L-methionine + fluoride
-
 Streptomyces cattleya 2'-deoxy-5'-fluoroadenosine + L-methionine in the reverse reaction the enzyme shows 10% activity with the 2'-deoxy compound compared to the activity with the 5'-derivative r
additional information fluoroacetate and 4-fluorothreonine accumulate in the fermentation media of Streptomyces cattleya at the mM level, when a fluoride source is added to the growth medium Streptomyces cattleya ?
-
 ?
S-adenosyl-L-methionine + fluoride
-
 Streptomyces cattleya 5'-deoxy-5'-fluoroadenosine + L-methionine
-
 r

Subunits

Subunits Comment Organism
hexamer a dimer of trimers Streptomyces cattleya

Synonyms

Synonyms Comment Organism
5'-FDA synthase
-
 Streptomyces cattleya
5'-fluoro-5'-deoxyadenosine synthase
-
 Streptomyces cattleya
fluorinase
-
 Streptomyces cattleya