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Literature summary for 2.5.1.60 extracted from

  • Gutkowska, M.; Wnuk, M.; Nowakowska, J.; Lichocka, M.; Stronkowski, M.M.; Swiezewska, E.
    Rab geranylgeranyl transferase beta subunit is essential for male fertility and tip growth in Arabidopsis (2015), J. Exp. Bot., 66, 213-224.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.60

Cloned(Commentary)

Cloned (Comment) Organism
gene rgtb1, the gene structure is very similar to that of its paralogue, AtRGTB2, except that the sequence corresponding to the first exon of AtRGTB2 is split into two shorter exons in the AtRGTB1 gene, sequnce comparison and expression analysis Arabidopsis thaliana
gene rgtb2, located on the third chromosome, comprises nine exons, and its structure is very similar to that of its paralogue, AtRGTB1, except that the sequence corresponding to the first exon of AtRGTB2 is split into two shorter exons in the AtRGTB1 gene, sequnce comparison and expression analysis Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information construction of enzyme disruption mutants Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q84J75 gene rgtb1
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Arabidopsis thaliana Q9LHL5 gene rgtb2
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Arabidopsis thaliana Col-0 Q84J75 gene rgtb1
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Arabidopsis thaliana Col-0 Q9LHL5 gene rgtb2
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Synonyms

Synonyms Comment Organism
Rab geranylgeranyl transferase
-
 Arabidopsis thaliana
RGT alphabeta
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana no upregulation of AtRGTB2 in Atrgtb1 homozygotes additional information

General Information

General Information Comment Organism
malfunction Atrgtb2 disruption mutnt plants are indistinguishable from the wild-type plants in their morphology and the time of flowering. Both homozygous Atrgtb2 mutants produces normal siliques, phenotype, overview Arabidopsis thaliana
malfunction partial impairment in this enzyme activity in Arabidopsis, by disruption of the AtRGTB1 gene, is known to influence plant stature and disturb gravitropic and light responses. Mutations in each of the RGTB genes cause a tip growth defect, visible as root hair and pollen tube deformations. FM 1-43 styryl dye endocytosis and recycling are affected in the mutant root hairs. The double mutant, with both AtRGTB genes disrupted, is non-viable due to absolute male sterility. Doubly mutated pollen is shrunken, has an abnormal exine structure, and shows strong disorganization of internal membranes, particularly of the endoplasmic reticulum system. The self-infertility of the Atrgtb1 mutants is not due solely to disturbed flower development. Siliques of homozygous Atrgtb1 mutants are smaller and rarely contain any seeds, phenotype, overview Arabidopsis thaliana
physiological function Rab proteins, key players in vesicular transport in all eukaryotic cells, are post-translationally modified by lipid moieties. Two geranylgeranyl groups are attached to the Rab protein by the heterodimeric enzyme Rab geranylgeranyl transferase (RGT) alphabeta Arabidopsis thaliana