Literature summary for 2.5.1.60 extracted from

Marma, M.S.; Xia, Z.; Stewart, C.; Coxon, F.; Dunford, J.E.; Baron, R.; Kashemirov, B.A.; Ebetino, F.H.; Triffitt, J.T.; Russell, R.G.; McKenna, C.E.
Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate (2007), J. Med. Chem., 50, 5967-5975.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-bromo-3-(3-pyridinyl)-2-phosphonopropionic acid	-	Rattus norvegicus
2-chloro-3-(3-pyridinyl)-2-phosphonopropionic acid	-	Rattus norvegicus
2-fluoro-3-(3-pyridinyl)-2-phosphonopropionic acid	-	Rattus norvegicus
3-(3-pyridinyl)-2-phosphonopropionic acid	-	Rattus norvegicus
3-pyridinyl ethylidene hydroxyl phosphonocarboxylate	previously known as NE10790	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranylgeranyl diphosphate + protein-cysteine	-	Rattus norvegicus	S-geranylgeranyl-protein + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
Rab geranylgeranyl transferase	-	Rattus norvegicus
RGGT	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0163	-	-	Rattus norvegicus	2-fluoro-3-(3-pyridinyl)-2-phosphonopropionic acid
0.0164	-	-	Rattus norvegicus	2-chloro-3-(3-pyridinyl)-2-phosphonopropionic acid
0.0177	-	-	Rattus norvegicus	2-bromo-3-(3-pyridinyl)-2-phosphonopropionic acid
0.0241	-	-	Rattus norvegicus	3-pyridinyl ethylidene hydroxyl phosphonocarboxylate
0.0353	-	-	Rattus norvegicus	3-(3-pyridinyl)-2-phosphonopropionic acid

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Release 2023.1 (January 2023)