Literature summary for 2.5.1.60 extracted from

Coxon, F.P.; Ebetino, F.H.; Mules, E.H.; Seabra, M.C.; McKenna, C.E.; Rogers, M.J.
Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo (2005), Bone, 37, 349-358.

Search for more literature for 2.5.1.60

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(3-pyridinyl)-1-ethylidene-1,1-phosphonocarboxylic acid	causes rapid accumulation of unprenylated Rabs within the cytosol of osteoclasts and macrophages due to specific inhibition of Rab GGTase	Mus musculus
2-(3-pyridinyl)-1-hydroxyethylidene-1,1-bisphosphonic acid	causes rapid accumulation of unprenylated Rabs within the cytosol of osteoclasts and macrophages due to specific inhibition of Rab GGTase	Mus musculus
2-(3-pyridinyl)-1-hydroxyethylidene-1,1-phosphonocarboxylic acid	causes rapid accumulation of unprenylated Rabs within the cytosol of osteoclasts and macrophages due to specific inhibition of Rab GGTase	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
J774.2 cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranylgeranyl diphosphate + Rab-protein-cysteine	-	Mus musculus	S-geranylgeranyl-Rab-protein + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
Rab geranylgeranyl transferase	-	Mus musculus
Rab GGTase	-	Mus musculus

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Release 2023.1 (January 2023)