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Literature summary for 2.5.1.60 extracted from
- Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys (1992), J. Biol. Chem., 267, 14497-14503.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KCl | 50% inhibition at 100 mM | Rattus norvegicus |  |
| NaCl | 50% inhibition at 100 mM | Rattus norvegicus | |
| NaOAc | 50% inhibition at 100 mM | Rattus norvegicus | |
| Zn2+ | in the presence of saturating concentrations of MgCl2 100% inhibition at 0.2 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00002 | - |
geranylgeranyl diphosphate | pH 7.2, 37°C | Rattus norvegicus | |
| 0.00002 | - |
Rab3A | pH 7.2, 37°C | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement, KM 0.5 mM | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38000 | - |
alpha,beta, 1 * 60000 + 1 * 38000 | Rattus norvegicus |
| 60000 | - |
alpha,beta, 1 * 60000 + 1 * 38000 | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| component B | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.03 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate + protein-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-protein + diphosphate | - |
? | |
| geranylgeranyl diphosphate + Rab1A | substrate motif: -XXCC | Rattus norvegicus | ? | - |
? | |
| geranylgeranyl diphosphate + Rab3A | substrate motif: -XCXC | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | alpha,beta, 1 * 60000 + 1 * 38000 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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