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Literature summary for 2.5.1.6 extracted from

  • Oh, T.J.; Niraula, N.P.; Liou, K.; Sohng, J.K.
    Identification of the duplicated genes for S-adenosyl-L-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952 (2010), J. Appl. Microbiol., 109, 398-407.
    View publication on PubMed
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
 x * 43000, SDS-PAGE and calculated Streptomyces peucetius

Organism

Organism UniProt Comment Textmining
Streptomyces peucetius Q05H71 isoform MetK2; strain ATCC 27952
-
Streptomyces peucetius Q05H72 isoform MetK1; strain ATCC 27952
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Streptomyces peucetius

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
 Streptomyces peucetius phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Subunits

Subunits Comment Organism
? x * 43000, SDS-PAGE and calculated Streptomyces peucetius

Expression

Organism Comment Expression
Streptomyces peucetius transcripts for the isoform metK1-sp are repressed as Streptomyces cells enter the decline phase down
Streptomyces peucetius transcripts for the isoform metK1-sp are induced as Streptomyces cells enter the decline phase up

General Information

General Information Comment Organism
physiological function doxorubicin production by the metK1-sp-deleted mutant is reduced Streptomyces peucetius