Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-methionine | 17% increase is observed at 60 mM L-methionine | Rattus norvegicus | |
L-methionine | 17% increase of activity is observed at 60 mM L-methionine | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | isozyme subunit MATalpha2 is inhibited by 0.25 mM Cu2+ in the presence or absence of dithiothreitol, strong reduction in MAT2B gene expression induced by Cu2+ (60%), copper effects can only be prevented by buthionine sulfoximine, whereas N-acetylcysteine and neocuproine are ineffective | Rattus norvegicus | |
L-methionine | 30% reduction in total activity is detected at 5 mM L-methionine; 30% reduction in total activity is detected at 5 mM L-methionine; 30% reduction in total activity is detected at 5 mM L-methionine | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
110000 | - |
isozyme MAT III, gel filtration | Rattus norvegicus |
200000 | - |
isozyme MAT I, gel filtration | Rattus norvegicus |
200000 | - |
isozyme MAT II, gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | P13444 | - |
- |
Rattus norvegicus | P18298 | - |
- |
Renatured (Comment) | Organism |
---|---|
dithiothreitol-refolding in the presence or absence of 250 mM CuSO4 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | - |
Rattus norvegicus | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | isozyme MAT III | Rattus norvegicus |
tetramer | isozyme MAT I | Rattus norvegicus |
tetramer | isozyme MAT II | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
MAT I | isozyme | Rattus norvegicus |
MAT II | isozyme | Rattus norvegicus |
MAT III | isozyme | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.287 | - |
isozyme subunit MATalpha2, in the absence of dithiothreitol | Rattus norvegicus | Cu2+ | |
0.748 | - |
isozyme subunit MATalpha2, in the presence of dithiothreitol | Rattus norvegicus | Cu2+ |