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Literature summary for 2.5.1.6 extracted from

  • Lu, S.C.; Martinez-Chantar, M.L.; Mato, J.M.
    Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease (2006), J. Gastroenterol. Hepatol., 21, S61-S64.
No PubMed abstract available
Search for more literature for 2.5.1.6

Application

Application Comment Organism
medicine S-adenosyl-L-methionine is applied to patients with alcoholic liver disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-methionine feedback inhibition of isozyme MAT II Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information different isoforms of MAT differ in kinetic and regulatory properties, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
 Homo sapiens
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Homo sapiens an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine, S-adenosyl-L-methionine is also a key metabolite that regulates hepatocyte growth, death and differentiation, molecular mechanism, overview, abnormalities in MAT and decreased S-adenosyl-L-methionine levels occur in humans with alcoholic liver disease, chronic hepatic S-adenosyl-L-methionine deficiency can result in the spontaneous development of steatohepatitis and hepatocellular carcinoma, overview, hepatic S-adenosyl-L-methionine biosynthesis and methionine metabolism, overview phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 genes MAT1A and MAT2A, isozymes MAT I-MAT III
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte in cultured hepatocytes MAT1A expression falls and MAT2A is induced when S-adenosyl-L-methionine level falls, which can be prevented by exogenous S-adenosyl-L-methionine Homo sapiens
-
liver expression of MAT1A, a marker for differentiated liver, MAT1A progressively replaces MAT2A, which is mainly expressed in fetal liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
 Homo sapiens phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?
ATP + L-methionine + H2O an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine, S-adenosyl-L-methionine is also a key metabolite that regulates hepatocyte growth, death and differentiation, molecular mechanism, overview, abnormalities in MAT and decreased S-adenosyl-L-methionine levels occur in humans with alcoholic liver disease, chronic hepatic S-adenosyl-L-methionine deficiency can result in the spontaneous development of steatohepatitis and hepatocellular carcinoma, overview, hepatic S-adenosyl-L-methionine biosynthesis and methionine metabolism, overview Homo sapiens phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Subunits

Subunits Comment Organism
dimer genes MAT1A and MAT2A encode catalytic subunits alpha1 and alpha2, respectively, the subunits differentially build the isozymes together with a regulatory beta subunit, isozyme composition, overview Homo sapiens

Synonyms

Synonyms Comment Organism
MAT
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens