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Literature summary for 2.5.1.6 extracted from
- Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met (2004), Biochemistry, 43, 1821-1831.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with 5-adenylyl imido triphosphate and methionine | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0A817 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine | neutral H14 acts as an acid to cleave the C5-O5 bond of ATP, S of methionine makes a nucleophilic attack on the C5 to form the product | Escherichia coli |
aSubunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | dimer of dimers, crystallization data | Escherichia coli |
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Release 2023.1 (January 2023)
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