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Literature summary for 2.5.1.6 extracted from

  • Halim, A.B.; LeGros, L.; Geller, A.; Kotb, M.
    Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells (1999), J. Biol. Chem., 274, 29720-29725.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
His-tagged recombinant MAT II alpha2 subunit expressed in COS-1 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
L-methionine
-
Homo sapiens
0.016
-
L-methionine alpha2-transfected MAT II, two kinetic forms Homo sapiens
0.02
-
L-methionine recombinant MAT II co-expressing alpha2 and beta subunits Homo sapiens
0.075
-
L-methionine alpha2-transfected MAT II, two kinetic forms Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
3 isoenzymes: MAT-I, MAT-II, MAT-III
-

Source Tissue

Source Tissue Comment Organism Textmining
liver MAT I/III isozymes Homo sapiens
-
additional information isoenzyme MAT-II present in all tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
Homo sapiens S-adenosyl-L-methionine + phosphate + diphosphate
-
?

Subunits

Subunits Comment Organism
More alpha2 and beta subunits of MAT II associate spontaneously Homo sapiens