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Literature summary for 2.5.1.6 extracted from

  • Chiang, P.K.; Cantoni, G.L.
    Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers yeast and its separation into two forms (1977), J. Biol. Chem., 252, 4506-4513.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
1 * 55000 + 1 * 60000, SDS-PAGE Saccharomyces cerevisiae
60000
-
1 * 55000 + 1 * 60000, SDS-PAGE Saccharomyces cerevisiae
110000
-
forms I and II, gel filtration Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
2 forms: I and II
-

Purification (Commentary)

Purification (Comment) Organism
partial, two forms: I and II Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
11
-
isoenzyme II Saccharomyces cerevisiae
18.7
-
isoenzyme I Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-ATP + L-methionine + H2O
-
Saccharomyces cerevisiae ?
-
?
3'-deoxy-ATP + L-methionine + H2O
-
Saccharomyces cerevisiae ?
-
?
ATP + L-ethionine + H2O
-
Saccharomyces cerevisiae S-adenosyl-L-ethionine + phosphate + diphosphate
-
?
ATP + L-methionine + H2O
-
Saccharomyces cerevisiae S-adenosyl-L-methionine + phosphate + diphosphate
-
?
tripolyphosphate + H2O tripolyphosphatase activity Saccharomyces cerevisiae diphosphate + phosphate
-
?
tripolyphosphate + H2O two isoenzymes with different behavior on exogenous S-adenosylmethionine addition Saccharomyces cerevisiae diphosphate + phosphate
-
?

Subunits

Subunits Comment Organism
dimer 1 * 55000 + 1 * 60000, SDS-PAGE Saccharomyces cerevisiae