Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | nanoformulation of geranylgeranyltransferase-I inhibitors for cancer therapy, liposomal encapsulation and pH-dependent delivery to cancer cells, scheme of synthesis of pH-responsive liposome and the proposed intracellular drug release pathway, method, overview. Liposomal GGTI inhibits protein geranylgeranylation inside the cell and this effect is dependent on the low pH of lysosomes; nanoformulation of geranylgeranyltransferase-I inhibitors for cancer therapy, liposomal encapsulation and pH-dependent delivery to cancer cells, scheme of synthesis of pH-responsive liposome and the proposed intracellular drug release pathway, method, overview. Liposomal GGTI inhibits protein geranylgeranylation inside the cell and this effect is dependent on the low pH of lysosomes | Homo sapiens | |
P61A6 | derived from an allenoate-derived compound library, shows efficiency of the enzyme inhibitor to inhibit tumor growth demonstrated using human pancreatic cancer xenograft; derived from an allenoate-derived compound library, shows efficiency of the enzyme inhibitor to inhibit tumor growth demonstrated using human pancreatic cancer xenograft | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine | Homo sapiens | the enzyme adds a C20 geranylgeranyl group to proteins such as RhoA, RhoC, Rap1 and Ral at the cysteine within the carboxy-terminal tetrapeptide consensus sequence CAAL (C is cysteine, A is an aliphatic amino acid, and the C-terminal residue is leucine or phenylalanine) | S-geranylgeranyl-protein + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49354 | subunit alpha | - |
Homo sapiens | P53609 | subunit beta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
BEAS-2B cell | - |
Homo sapiens | - |
bronchial epithelium cell | - |
Homo sapiens | - |
H-358 cell | - |
Homo sapiens | - |
H-596 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MiaPaCa-2 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine | - |
Homo sapiens | S-geranylgeranyl-protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | the enzyme adds a C20 geranylgeranyl group to proteins such as RhoA, RhoC, Rap1 and Ral at the cysteine within the carboxy-terminal tetrapeptide consensus sequence CAAL (C is cysteine, A is an aliphatic amino acid, and the C-terminal residue is leucine or phenylalanine) | Homo sapiens | S-geranylgeranyl-protein + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
geranylgeranyltransferase-I | - |
Homo sapiens |
GGTase I | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | GGTase-I inhibition results in proliferation inhibition associated with G1 arrest and accumulation of cell cycle regulators such as p21CIP1/WAF1 | Homo sapiens |
physiological function | importance of GGTase-I in cell proliferation and cell cycle progression | Homo sapiens |