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Literature summary for 2.5.1.59 extracted from
- Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I (2006), J. Lipid Res., 47, 681-699.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-778,123 | - |
Rattus norvegicus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | required for catalysis and peptide binding, one zinc ion per protein dimer | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
1 * 43000 + 1 * 48000 | Rattus norvegicus |
| 48000 | - |
1 * 43000 + 1 * 48000 | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate + Cys-Val-Leu-Leu | - |
Rattus norvegicus | S-geranylgeranyl-Cys-Val-Leu-Leu + diphosphate | - |
? | |
| geranylgeranyl diphosphate + Cys-Val-Leu-Ser | - |
Rattus norvegicus | S-geranylgeranyl-Cys-Val-Leu-Ser + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 43000 + 1 * 48000 | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| geranylgeranyltransferase type I | - |
Rattus norvegicus |
| GGTase-I | - |
Rattus norvegicus |
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