Literature summary for 2.5.1.59 extracted from

Dursina, B.; Reents, R.; Delon, C.; Wu, Y.; Kulharia, M.; Thutewohl, M.; Veligodsky, A.; Kalinin, A.; Evstifeev, V.; Ciobanu, D.; Szedlacsek, S.E.; Waldmann, H.; Goody, R.S.; Alexandrov, K.
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids (2006), J. Am. Chem. Soc., 128, 2822-2835.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00003	-	3,7,11-trimethyl-12-(7-nitro-benzo[1,2,5]-oxadiazo-4-ylamino)-dodeca-2,6,10-trien-1-diphosphate	-	Homo sapiens
0.042	-	GST-RhoA	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,7,11-trimethyl-12-(7-nitro-benzo[1,2,5]-oxadiazo-4-ylamino)-dodeca-2,6,10-trien-1-diphosphate + GST-RhoA	-	Homo sapiens	diphosphate + ?	-	?
3,7-dimethyl-8-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-octa-2,6-diene-1-diphosphate + GST-RhoA	-	Homo sapiens	diphosphate + ?	-	?
geranylgeranyl diphosphate + GST-RhoA	-	Homo sapiens	diphosphate + GST-S-geranylgeranyl-RhoA	-	?

Synonyms

Synonyms	Comment	Organism
PGGTase-I	-	Homo sapiens
protein geranylgeranyltransferase type-I	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.08	-	GST-RhoA	-	Homo sapiens
0.08	-	3,7,11-trimethyl-12-(7-nitro-benzo[1,2,5]-oxadiazo-4-ylamino)-dodeca-2,6,10-trien-1-diphosphate	-	Homo sapiens

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Release 2023.1 (January 2023)