Literature summary for 2.5.1.59 extracted from

Terry, K.L.; Casey, P.J.; Beese, L.S.
Conversion of protein farnesyltransferase to a geranylgeranyltransferase (2006), Biochemistry, 45, 9746-9755.

Search for more literature for 2.5.1.59

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00000133	-	Asp-Asp-Pro-Thr-Ala-Ser-Ala-Cys-Val-Leu-Leu	at 30°C	Homo sapiens
0.00003934	-	geranylgeranyl diphosphate	at 30°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranylgeranyl diphosphate + Asp-Asp-Pro-Thr-Ala-Ser-Ala-Cys-Val-Leu-Leu	-	Homo sapiens	Asp-Asp-Pro-Thr-Ala-Ser-Ala-(S-geranylgeranyl)-Cys-Val-Leu-Leu + diphosphate	-	?
geranylgeranyl diphosphate + protein-cysteine	-	Homo sapiens	S-geranylgeranyl-protein + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
PGGTase-I	-	Homo sapiens
protein geranylgeranyltransferase type-I	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.021	-	geranylgeranyl diphosphate	at 30°C	Homo sapiens
0.021	-	Asp-Asp-Pro-Thr-Ala-Ser-Ala-Cys-Val-Leu-Leu	at 30°C	Homo sapiens

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Release 2023.1 (January 2023)