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Literature summary for 2.5.1.58 extracted from
- Introduction of methionine mimics on 3-arylthiophene: Influence on protein farnesyltransferase inhibition and on antiparasitic activity (2013), MedChemComm, 4, 1034-1041.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid | - |
Homo sapiens |  |
| (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid | - |
Trypanosoma brucei | |
| (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid | - |
Homo sapiens | |
| (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid | - |
Trypanosoma brucei | |
| 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide | - |
Homo sapiens | |
| 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide | - |
Trypanosoma brucei | |
| 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
| 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
| 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide | - |
Homo sapiens | |
| 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide | - |
Trypanosoma brucei | |
| 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | - |
Homo sapiens | |
| 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | - |
Trypanosoma brucei | |
| 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | - |
Homo sapiens | |
| 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | - |
Trypanosoma brucei | |
| 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
| 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
| 4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
| 4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
| 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
| 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
| 4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
| 4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
| 5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid | - |
Homo sapiens | |
| 5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
| ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate | - |
Homo sapiens | |
| ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate | - |
Trypanosoma brucei | |
| ethyl 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate | - |
Homo sapiens | |
| ethyl 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate | - |
Trypanosoma brucei | |
| ethyl 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate | - |
Homo sapiens | |
| ethyl 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate | - |
Trypanosoma brucei | |
| ethyl N-(tert-butoxycarbonyl)-N-[2-(methylsulfanyl)ethyl]glycinate | - |
Homo sapiens | |
| ethyl N-(tert-butoxycarbonyl)-N-[2-(methylsulfanyl)ethyl]glycinate | - |
Trypanosoma brucei | |
| ethyl N-(tert-butoxycarbonyl)glycinate | - |
Homo sapiens | |
| ethyl N-(tert-butoxycarbonyl)glycinate | - |
Trypanosoma brucei | |
| ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate | - |
Homo sapiens | |
| ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate | - |
Trypanosoma brucei | |
| methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate | - |
Homo sapiens | |
| methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate | - |
Trypanosoma brucei | |
| methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate | - |
Homo sapiens | |
| methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate | - |
Trypanosoma brucei | |
| methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate | - |
Homo sapiens | |
| methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate | - |
Trypanosoma brucei | |
| methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Homo sapiens | |
| methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Trypanosoma brucei | |
| methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Homo sapiens | |
| methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Trypanosoma brucei | |
| methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Homo sapiens | |
| methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Trypanosoma brucei | |
| methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Homo sapiens | |
| methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate | - |
Trypanosoma brucei | |
| methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate | - |
Homo sapiens | |
| methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate | - |
Trypanosoma brucei | |
| additional information | addition of a methionine residue at position 2 of 3-arylthiophenes greatly improves enzyme inhibition, antiparasitic effect of the compounds on proliferation of 4 protozoan parasites, i.e. Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania donovani, overview. No inhibition by 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-(adamant-1-ylmethyl)thiophene-2-carboxamide, 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-ylmethyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide, methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methioninate, ethyl 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate, and methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | Homo sapiens | |
| additional information | addition of a methionine residue at position 2 of 3-arylthiophenes greatly improves enzyme inhibition, antiparasitic effect of the compounds on proliferation of 4 protozoan parasites, i.e. Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania donovani, overview. No inhibition by 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-(adamant-1-ylmethyl)thiophene-2-carboxamide, 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-ylmethyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide, methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methioninate, ethyl 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate, and methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | Trypanosoma brucei | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine | - |
Homo sapiens | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine | - |
Trypanosoma brucei | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine | - |
Homo sapiens | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine | - |
Trypanosoma brucei | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine | - |
Homo sapiens | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine | - |
Trypanosoma brucei | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Homo sapiens | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Trypanosoma brucei | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine | - |
Homo sapiens | |
| N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine | - |
Trypanosoma brucei | |
| N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Homo sapiens | |
| N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Trypanosoma brucei | |
| N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Homo sapiens | |
| N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Trypanosoma brucei | |
| N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Homo sapiens | |
| N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine | - |
Trypanosoma brucei | |
| N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine | - |
Homo sapiens | |
| N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine | - |
Trypanosoma brucei | |
| tert-butyl 2-[2-(methylsulfanyl)ethyl]hydrazinecarboxylate | - |
Homo sapiens | |
| tert-butyl 2-[2-(methylsulfanyl)ethyl]hydrazinecarboxylate | - |
Trypanosoma brucei | |
| [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid | - |
Homo sapiens | |
| [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid | - |
Trypanosoma brucei | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | Homo sapiens | - |
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | Trypanosoma brucei | - |
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Trypanosoma brucei | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | - |
Homo sapiens | S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? | |
| (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | - |
Trypanosoma brucei | S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hFTase | - |
Homo sapiens |
| TbFTase | - |
Trypanosoma brucei |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000042 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.000042 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.000067 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.000076 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine | |
| 0.000077 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.000079 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.00012 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.00014 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.00019 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.00023 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine | |
| 0.00045 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine | |
| 0.00046 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate | |
| 0.00053 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid | |
| 0.0012 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine | |
| 0.0014 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine | |
| 0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine | |
| 0.0018 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine | |
| 0.0019 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide | |
| 0.0019 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide | |
| 0.0019 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine | |
| 0.0022 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine | |
| 0.0028 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate | |
| 0.0033 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine | |
| 0.0036 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.0037 | - |
pH and temperature not specified in the publication | Homo sapiens | [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid | |
| 0.0047 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.0048 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.0053 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.0056 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.0082 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate | |
| 0.0087 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine | |
| 0.0089 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid | |
| 0.0093 | - |
pH and temperature not specified in the publication | Homo sapiens | ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate | |
| 0.0104 | - |
pH and temperature not specified in the publication | Homo sapiens | (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid | |
| 0.011 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
| 0.016 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
| 0.019 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.02 | - |
about, pH and temperature not specified in the publication | Homo sapiens | 5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid | |
| 0.0216 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | |
| 0.022 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate | |
| 0.023 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.024 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | |
| 0.024 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | |
| 0.029 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid | |
| 0.05 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.05 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate | |
| 0.05 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate | |
| 0.05 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate | |
| 0.05 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate | |
| 0.05 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate | |
| 0.05 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide | |
| 0.05 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide | |
| 0.05 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide | |
| 0.05 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate | |
| 0.05 | - |
pH and temperature not specified in the publication | Homo sapiens | ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate | |
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Release 2023.1 (January 2023)
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