Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | - |
Homo sapiens | |
(2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | - |
Saccharomyces cerevisiae | |
(4E,8E)-2-(ethoxycarbonyl)-5,9,13-trimethyl-2-[3-(1-methyl-1H-imidazol-2-yl)propyl]tetradeca-4,8,12-trienoic acid | - |
Homo sapiens | |
(4E,8E)-2-(ethoxycarbonyl)-5,9,13-trimethyl-2-[3-(1-methyl-1H-imidazol-2-yl)propyl]tetradeca-4,8,12-trienoic acid | 50% growth inhibition at 0.004 mM | Plasmodium falciparum | |
(4E,8E)-2-(ethoxycarbonyl)-5,9,13-trimethyl-2-[3-(1-methyl-1H-imidazol-2-yl)propyl]tetradeca-4,8,12-trienoic acid | - |
Trypanosoma brucei | |
(4E,8E)-5,9,13-trimethyl-N-(phenylsulfonyl)tetradeca-4,8,12-trienamide | - |
Homo sapiens | |
(4E,8E)-5,9,13-trimethyl-N-(phenylsulfonyl)tetradeca-4,8,12-trienamide | - |
Saccharomyces cerevisiae | |
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienamide | - |
Homo sapiens | |
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | - |
Homo sapiens | |
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | - |
Saccharomyces cerevisiae | |
(4E,8E)-N-hydroxy-5,9,13-trimethyltetradeca-4,8,12-trienamide | - |
Homo sapiens | |
(6E,10E)-7,11,15-trimethyl-3-oxohexadeca-6,10,14-trienoic acid | - |
Homo sapiens | |
(6E,10E)-7,11,15-trimethyl-3-oxohexadeca-6,10,14-trienoic acid | - |
Saccharomyces cerevisiae | |
(7E,11E)-8,12,16-trimethyl-4-oxoheptadeca-7,11,15-trienoic acid | - |
Homo sapiens | |
(7E,11E)-8,12,16-trimethyl-4-oxoheptadeca-7,11,15-trienoic acid | - |
Saccharomyces cerevisiae | |
3-oxo-3-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanoic acid | - |
Homo sapiens | |
3-oxo-3-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanoic acid | - |
Saccharomyces cerevisiae | |
4-oxo-4-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]butanoic acid | - |
Homo sapiens | |
4-oxo-4-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]butanoic acid | - |
Saccharomyces cerevisiae | |
5-oxo-5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentanoic acid | - |
Homo sapiens | |
5-oxo-5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentanoic acid | - |
Saccharomyces cerevisiae | |
chaetomellic acid A | - |
Homo sapiens | |
chaetomellic acid A | - |
Saccharomyces cerevisiae | |
methyl N-([2-[(1E,6E,10E)-4,4-bis(ethoxycarbonyl)-7,11,15-trimethylhexadeca-1,6,10,14-tetraen-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | 50% growth inhibition at 0.0011 mM | Plasmodium falciparum | |
methyl N-([2-[(1E,6E,10E)-4,4-bis(ethoxycarbonyl)-7,11,15-trimethylhexadeca-1,6,10,14-tetraen-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | - |
Trypanosoma brucei | |
methyl N-([2-[(6E,10E)-4,4-bis(ethoxycarbonyl)-7,11,15-trimethylhexadeca-6,10,14-trien-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | 50% growth inhibition at 0.001 mM | Plasmodium falciparum | |
methyl N-([2-[(6E,10E)-4,4-bis(ethoxycarbonyl)-7,11,15-trimethylhexadeca-6,10,14-trien-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | - |
Trypanosoma brucei | |
N-([2-[(1E,6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-1,6,10,14-tetraen-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine | - |
Homo sapiens | |
N-([2-[(1E,6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-1,6,10,14-tetraen-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine | 50% growth inhibition at 0.0172 mM | Plasmodium falciparum | |
N-([2-[(6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-6,10,14-trien-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine | - |
Homo sapiens | |
N-([2-[(6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-6,10,14-trien-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine | 50% growth inhibition at 0.0314 mM | Plasmodium falciparum | |
[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]propanedioic acid | - |
Homo sapiens | |
[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]propanedioic acid | - |
Saccharomyces cerevisiae | |
[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | - |
Homo sapiens | |
[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | - |
Saccharomyces cerevisiae | |
[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]sulfamic acid | - |
Homo sapiens | |
[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]sulfamic acid | - |
Saccharomyces cerevisiae | |
[3-(1-methyl-1H-imidazol-2-yl)propyl][(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | - |
Homo sapiens | |
[3-(1-methyl-1H-imidazol-2-yl)propyl][(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | - |
Plasmodium falciparum | |
[3-(1-methyl-1H-imidazol-2-yl)propyl][(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | - |
Trypanosoma brucei | |
[[(2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoyl]amino]propanedioic acid | - |
Saccharomyces cerevisiae | |
[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanedioic acid | - |
Homo sapiens | |
[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanedioic acid | - |
Saccharomyces cerevisiae | |
[[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]amino]propanedioic acid | - |
Homo sapiens | |
[[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]amino]propanedioic acid | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
FTase | - |
Homo sapiens |
FTase | - |
Saccharomyces cerevisiae |
FTase | - |
Trypanosoma brucei |
FTase | - |
Plasmodium falciparum |
protein farnesyltransferase | - |
Homo sapiens |
protein farnesyltransferase | - |
Saccharomyces cerevisiae |
protein farnesyltransferase | - |
Trypanosoma brucei |
protein farnesyltransferase | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
30 | - |
assay at | Saccharomyces cerevisiae |
30 | - |
assay at | Trypanosoma brucei |
30 | - |
assay at | Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Saccharomyces cerevisiae |
7.5 | - |
assay at | Trypanosoma brucei |
7.5 | - |
assay at | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000175 | - |
30°C, pH 7.5 | Homo sapiens | chaetomellic acid A | |
0.00024 | - |
30°C, pH 7.5 | Homo sapiens | N-([2-[(6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-6,10,14-trien-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine | |
0.00034 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | chaetomellic acid A | |
0.00064 | - |
30°C, pH 7.5 | Homo sapiens | N-([2-[(1E,6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-1,6,10,14-tetraen-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine | |
0.00088 | - |
30°C, pH 7.5 | Homo sapiens | [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | |
0.0009 | - |
30°C, pH 7.5 | Homo sapiens | [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]propanedioic acid | |
0.004 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | |
0.005 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | [[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanedioic acid | |
0.01 | - |
30°C, pH 7.5 | Homo sapiens | [[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanedioic acid | |
0.015 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (7E,11E)-8,12,16-trimethyl-4-oxoheptadeca-7,11,15-trienoic acid | |
0.021 | - |
30°C, pH 7.5 | Homo sapiens | [3-(1-methyl-1H-imidazol-2-yl)propyl][(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid | |
0.035 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | 5-oxo-5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentanoic acid | |
0.04 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | |
0.042 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | |
0.06 | - |
30°C, pH 7.5 | Homo sapiens | (7E,11E)-8,12,16-trimethyl-4-oxoheptadeca-7,11,15-trienoic acid | |
0.06 | - |
30°C, pH 7.5 | Homo sapiens | 5-oxo-5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentanoic acid | |
0.06 | - |
30°C, pH 7.5 | Homo sapiens | [[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]amino]propanedioic acid | |
0.08 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (6E,10E)-7,11,15-trimethyl-3-oxohexadeca-6,10,14-trienoic acid | |
0.08 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | 3-oxo-3-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanoic acid | |
0.085 | - |
30°C, pH 7.5 | Homo sapiens | [(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]sulfamic acid | |
0.1 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | 4-oxo-4-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]butanoic acid | |
0.13 | - |
30°C, pH 7.5 | Homo sapiens | (2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid | |
0.13 | - |
30°C, pH 7.5 | Homo sapiens | 4-oxo-4-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]butanoic acid | |
0.16 | - |
30°C, pH 7.5 | Homo sapiens | 3-oxo-3-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanoic acid | |
0.17 | - |
30°C, pH 7.5 | Homo sapiens | (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid | |
0.2 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | (4E,8E)-5,9,13-trimethyl-N-(phenylsulfonyl)tetradeca-4,8,12-trienamide | |
0.2 | - |
30°C, pH 7.5 | Homo sapiens | (6E,10E)-7,11,15-trimethyl-3-oxohexadeca-6,10,14-trienoic acid | |
0.2 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | [(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]sulfamic acid | |
0.2 | - |
30°C, pH 7.5 | Saccharomyces cerevisiae | [[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]amino]propanedioic acid | |
0.2 | - |
value above, 30°C, pH 7.5 | Homo sapiens | (4E,8E)-5,9,13-trimethyl-N-(phenylsulfonyl)tetradeca-4,8,12-trienamide | |
0.2 | - |
value above, 30°C, pH 7.5 | Homo sapiens | (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienamide |