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Literature summary for 2.5.1.58 extracted from

  • Reigard, S.A.; Zahn, T.J.; Haworth, K.B.; Hicks, K.A.; Fierke, C.A.; Gibbs, R.A.
    Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase (2005), Biochemistry, 44, 11214-11223.
    View publication on PubMed
Search for more literature for 2.5.1.58

Inhibitors

Inhibitors Comment Organism Structure
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate farnesylation of dansyl-GCKVL, IC5=: 510 nM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00014
-
 dansyl-Gly-Cys-Val-Ile-Met cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus
0.00016
-
 dansyl-Gly-Cys-Val-Ile-Met cosubstrate: farnesyl diphosphate Rattus norvegicus
0.0005
-
 dansyl-Gly-Cys-Lys-Thr-Gln cosubstrate: farnesyl diphosphate Rattus norvegicus
0.0007
-
 dansyl-Gly-Cys-Val-Leu-Ser cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus
0.0007
-
 dansyl-Gly-Cys-Val-Leu-Ser cosubstrate: farnesyl diphosphate Rattus norvegicus
0.0007
-
 dansyl-Gly-Cys-Lys-Val-Leu cosubstrate: farnesyl diphosphate Rattus norvegicus
0.0018
-
 dansyl-Gly-Cys-Lys-Thr-Gln cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus
0.0025
-
 dansyl-Gly-Cys-Lys-Val-Leu cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
farnesyl diphosphate + protein-cysteine Rattus norvegicus catalyzes the post-translational modification of many important cellular proteins S-farnesyl protein + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Lys-Thr-Gln
-
 Rattus norvegicus ? + diphosphate
-
 ?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Lys-Val-Leu
-
 Rattus norvegicus ? + diphosphate
-
 ?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Val-Ile-Met
-
 Rattus norvegicus ? + diphosphate
-
 ?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Val-Leu-Ser
-
 Rattus norvegicus ? + diphosphate
-
 ?
farnesyl diphosphate + dansyl-Gly-Cys-Lys-Thr-Gln
-
 Rattus norvegicus dansyl-Gly-S-farnesyl-Cys-Lys-Thr-Gln + diphosphate
-
 ?
farnesyl diphosphate + dansyl-Gly-Cys-Lys-Val-Leu
-
 Rattus norvegicus dansyl-Gly-S-farnesyl-Cys-Lys-Val-Leu + diphosphate
-
 ?
farnesyl diphosphate + dansyl-Gly-Cys-Val-Ile-Met
-
 Rattus norvegicus dansyl-Gly-S-farnesyl-Cys-Val-Ile-Met + diphosphate
-
 ?
farnesyl diphosphate + dansyl-Gly-Cys-Val-Leu-Ser
-
 Rattus norvegicus dansyl-Gly-S-farnesyl-Cys-Val-Leu-Ser + diphosphate
-
 ?
farnesyl diphosphate + protein-cysteine catalyzes the post-translational modification of many important cellular proteins Rattus norvegicus S-farnesyl protein + diphosphate
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.009
-
 dansyl-Gly-Cys-Val-Ile-Met cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus
0.009
-
 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate cosubstrate: dansyl-Gly-Cys-Val-Ile-Met Rattus norvegicus
0.01
-
 farnesyl diphosphate cosubstrate: dansyl-Gly-Cys-Val-Ile-Met Rattus norvegicus
0.01
-
 dansyl-Gly-Cys-Val-Ile-Met cosubstrate: farnesyl diphosphate Rattus norvegicus
0.015
-
 dansyl-Gly-Cys-Lys-Val-Leu cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus
0.015
-
 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate cosubstrate: dansyl-Gly-Cys-Lys-Val-Leu Rattus norvegicus
0.022
-
 farnesyl diphosphate cosubstrate: dansyl-Gly-Cys-Lys-Thr-Gln Rattus norvegicus
0.022
-
 dansyl-Gly-Cys-Lys-Thr-Gln cosubstrate: farnesyl diphosphate Rattus norvegicus
0.033
-
 dansyl-Gly-Cys-Lys-Thr-Gln cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus
0.033
-
 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate cosubstrate: dansyl-Gly-Cys-Lys-Thr-Gln Rattus norvegicus
0.045
-
 farnesyl diphosphate cosubstrate: dansyl-Gly-Cys-Lys-Val-Leu Rattus norvegicus
0.045
-
 dansyl-Gly-Cys-Lys-Val-Leu cosubstrate: farnesyl diphosphate Rattus norvegicus
0.058
-
 dansyl-Gly-Cys-Val-Leu-Ser cosubstrate: 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate Rattus norvegicus
0.058
-
 3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate cosubstrate: dansyl-Gly-Cys-Val-Leu-Ser Rattus norvegicus
0.13
-
 farnesyl diphosphate cosubstrate: dansyl-Gly-Cys-Val-Leu-Ser Rattus norvegicus
0.13
-
 dansyl-Gly-Cys-Val-Leu-Ser cosubstrate: farnesyl diphosphate Rattus norvegicus