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Literature summary for 2.5.1.58 extracted from

  • Turek-Etienne, T.C.; Strickland, C.L.; Distefano, M.D.
    Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase (2003), Biochemistry, 42, 3716-3724.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
complex of enzyme with (E,E)-[alpha,beta(n)-32P]-8-O-(3-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene 1-diphosphate and of the enzyme with geranylgeranyl diphosphate Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
(E,E)-8-O-(3-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene 1-diphosphate
-
Saccharomyces cerevisiae
(E,E)-8-O-(4-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene 1-diphosphate
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + Ds-GCVIA
-
Saccharomyces cerevisiae diphosphate + ?
-
?

Synonyms

Synonyms Comment Organism
yPFTase
-
Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.045
-
(E,E)-8-O-(4-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene 1-diphosphate
-
Saccharomyces cerevisiae
0.049
-
(E,E)-8-O-(3-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene 1-diphosphate
-
Saccharomyces cerevisiae