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Literature summary for 2.5.1.58 extracted from

  • Gomez, R.; Goodman, L.E.; Tripathy, S.K.; O'Rourke, E.; Manne, V.; Tamanoi, F.
    Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart (1993), Biochem. J., 289, 25-31.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine
-
Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme inhibited by peptides containing the C-terminal CAAX sequence Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0051
-
GST-CIIS
-
Saccharomyces cerevisiae
0.0081
-
farnesyl diphosphate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
1 * 43000 + 1 * 34000 Saccharomyces cerevisiae
43000
-
1 * 43000 + 1 * 34000 Saccharomyces cerevisiae
90000
-
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + GST-CIIL
-
Saccharomyces cerevisiae diphosphate + S-farnesyl-GST-Cys-Ile-Ile-Ser
-
?
farnesyl diphosphate + GST-CIIS GST-CIIS is glutathione S-transferase fused to the C-terminal 12 amino acids of yeast RAS2 protein Saccharomyces cerevisiae ?
-
?
farnesyl diphosphate + protein-cysteine prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F Saccharomyces cerevisiae diphosphate + S-farnesyl protein
-
?
farnesyl diphosphate + [GST]-Cys-Ile-Ile-Ser
-
Saccharomyces cerevisiae diphosphate + S-farnesyl-[GST]-Cys-Ile-Ile-Ser
-
?

Subunits

Subunits Comment Organism
heterodimer 1 * 43000 + 1 * 34000 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
-
Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
Saccharomyces cerevisiae