Literature summary for 2.5.1.55 extracted from

Wen, L.; Zheng, Y.; Li, T.; Wang, P.G.
Enzymatic synthesis of 3-deoxy-D-manno-octulosonic acid (KDO) and its application for LPS assembly (2016), Bioorg. Med. Chem. Lett., 26, 2825-2828.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O	Escherichia coli	-	3-deoxy-D-manno-octulosonate 8-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	development of a one-pot enzyme essay for 3-deoxy-D-manno-octulosonate 8-phosphate synthesis, the reaction process involves the isomerization of D-ribulose 5-phosphate to D-arabinose 5-phosphate catalyzed by D-arabinose 5-phosphate isomerase (KdsD), the aldol condensation of D-arabinose 5-phosphate and phosphoenolpyruvate (PEP) catalyzed by KDO 8-phosphate synthetase (KdsA), and the hydrolysis of KDO-8-phosphate catalyzed by KDO 8-phosphate phosphatase (KdsC), the poduct is transferred to lipid A by KDO transferase from Escherichia coli (WaaA), method, overview	Escherichia coli	?	-	?
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O	-	Escherichia coli	3-deoxy-D-manno-octulosonate 8-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
KDO 8-phosphate synthetase	-	Escherichia coli
KdsA	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	the enzyme synthesizes 3-deoxy-D-manno-octulosonic acid, that is an important component of the nonrepeating core oligosaccharide part of bacterial lipopolysaccharides and in capsular polysaccharides of many bacteria	Escherichia coli

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Release 2023.1 (January 2023)