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Literature summary for 2.5.1.55 extracted from
- Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno-octulosonate 8-phosphate synthases (2007), Biochemistry, 46, 4532-4544.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Aquifex aeolicus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Aquifex aeolicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C11N | mutant is not capable of binding metal and lacks the structural asymmetry among subunits with regard to substrate binding and conformation of the L7 loop, shows decreased thermal stability | Aquifex aeolicus |
| C11N/S235P/Q237A | mutant is not capable of binding metal and lacks the structural asymmetry among subunits with regard to substrate binding and conformation of the L7 loop, shows decreased thermal stability | Aquifex aeolicus |
| P10M/C11N | mutant is not capable of binding metal and lacks the structural asymmetry among subunits with regard to substrate binding and conformation of the L7 loop, shows decreased thermal stability | Aquifex aeolicus |
| P10M/C11N/S235P/Q237A | mutant is not capable of binding metal and lacks the structural asymmetry among subunits with regard to substrate binding and conformation of the L7 loop, shows decreased thermal stability | Aquifex aeolicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | 0.05 mM | Aquifex aeolicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aquifex aeolicus | O66496 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Aquifex aeolicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + D-arabinose 5-phosphate + H2O | - |
Aquifex aeolicus | 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-deoxy-D-manno-octulosonate 8-phosphate synthase | - |
Aquifex aeolicus |
| EC 4.1.2.16 | formerly | Aquifex aeolicus |
| Kdo8P synthase | - |
Aquifex aeolicus |
| KDO8PS | - |
Aquifex aeolicus |
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Release 2023.1 (January 2023)
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