Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of deoxyhypusine synthase knockout mutants using siRNA via Agrobacterium strainGV3101/pMP90 transfection in Arabidopsis thaliana | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[eIF5A-precursor]-lysine + spermidine | Arabidopsis thaliana | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
[eIF5A-precursor]-lysine + spermidine | Arabidopsis thaliana Col-0 | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9FI94 | gene dhs | - |
Arabidopsis thaliana Col-0 | Q9FI94 | gene dhs | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[eIF5A-precursor]-lysine + spermidine | - |
Arabidopsis thaliana | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
[eIF5A-precursor]-lysine + spermidine | transfer of a 4-aminobutyl moiety group | Arabidopsis thaliana | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
[eIF5A-precursor]-lysine + spermidine | - |
Arabidopsis thaliana Col-0 | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
[eIF5A-precursor]-lysine + spermidine | transfer of a 4-aminobutyl moiety group | Arabidopsis thaliana Col-0 | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | early flowering phenotype of dexamethasone-treated siDHS knockout transgenic plants, hypersensitivityof siDHS transgenic plants to osmotic stressors and abscisic acid. The sensitivity of transgenic siDHS plantsto abscisic acid in the absence of the silencing drug dexamethasone probably reflects that the genetic inactivation system is slightly leaky and that minor inactivation of the eIF5A pathway is very sensitive to alterations in abscisic acid homeostasis. Non-silenced siDHS plants display partial growth inhibition under salt treatment. Alterations in root cell expansion and root hair phenotypes caused by DHS silencing, overview | Arabidopsis thaliana |
physiological function | the enzyme is required for spermidine-mediated activation of eIF5A by hypusination. Activated elF5A is involved in several aspects of plant biology such as the control of flowering time, the aerial and root architecture, and root hair growth. In addition, the pathway is required for adaptation to challenging growth conditions such as high salt and high glucose medium and to elevated concentrations of the plant hormone abscisic acid | Arabidopsis thaliana |