General Stability | Organism |
---|---|
increased instability with higher purification grade | Eupatorium cannabinum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-diaminopropane | competitive | Eupatorium cannabinum | |
cadaverine | mixed type inhibition | Eupatorium cannabinum | |
Homospermidine | competitive | Eupatorium cannabinum | |
spermidine | competitive | Eupatorium cannabinum | |
spermine | mixed type inhibition | Eupatorium cannabinum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
NAD+ | NAD+ functions as an enzyme-bound redoxsystem that is reduced in the first and reoxidized in the second part of the overall reaction. It functions as a coenzyme and not a cosubstrate | Eupatorium cannabinum | |
0.0135 | - |
putrescine | in the absence of spermidine | Eupatorium cannabinum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
putrescine + spermine | Eupatorium cannabinum | - |
sym-homospermine + propane-1,3-diamine | - |
? | |
putrescine + spermine | Eupatorium pauciflorum | - |
sym-homospermine + propane-1,3-diamine | - |
? | |
putrescine + spermine | Jacobaea vulgaris | - |
sym-homospermine + propane-1,3-diamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Eupatorium cannabinum | - |
- |
- |
Eupatorium pauciflorum | - |
- |
- |
Jacobaea vulgaris | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Eupatorium cannabinum | - |
root | - |
Eupatorium pauciflorum | - |
root | - |
Jacobaea vulgaris | - |
tissue culture | - |
Eupatorium cannabinum | - |
tissue culture | - |
Eupatorium pauciflorum | - |
tissue culture | - |
Jacobaea vulgaris | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.047 | - |
- |
Eupatorium cannabinum |
Storage Stability | Organism |
---|---|
4°C, crude extract, 0.5-1 mM spermidine, 0.5-1 mM NAD+, 1 week, 30% loss of activity | Eupatorium cannabinum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
putrescine + spermidine | - |
Eupatorium cannabinum | N-(4-aminobutyl)butane-1,4-diamine + propane-1,3-diamine | - |
? | |
putrescine + spermidine | - |
Eupatorium pauciflorum | N-(4-aminobutyl)butane-1,4-diamine + propane-1,3-diamine | - |
? | |
putrescine + spermidine | - |
Jacobaea vulgaris | N-(4-aminobutyl)butane-1,4-diamine + propane-1,3-diamine | - |
? | |
putrescine + spermine | - |
Eupatorium cannabinum | sym-homospermine + propane-1,3-diamine | - |
? | |
putrescine + spermine | - |
Eupatorium pauciflorum | sym-homospermine + propane-1,3-diamine | - |
? | |
putrescine + spermine | - |
Jacobaea vulgaris | sym-homospermine + propane-1,3-diamine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | the NADH formed in the first part of the reaction, i.e. oxidative deamination of putrescine, is cosubstrate of the second part of the reaction, i.e. hydrogenation of an intermolecular Schiff's base between the semialdehyde in the reaction and the second putrescine unit | Eupatorium cannabinum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
spermine | - |
Eupatorium cannabinum | |
0.0063 | - |
1,3-diaminopropane | - |
Eupatorium cannabinum | |
0.058 | - |
cadaverine | - |
Eupatorium cannabinum | |
0.094 | - |
spermidine | - |
Eupatorium cannabinum | |
0.95 | - |
Homospermidine | - |
Eupatorium cannabinum |