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Literature summary for 2.5.1.4 extracted from
- Enzymatic cleavage of S-adenosylmethionine (1959), J. Biol. Chem., 234, 87-92.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5'-O-Methyladenosine | weak inhibition | Saccharomyces cerevisiae |  |
| adenine | weak inhibition | Saccharomyces cerevisiae | |
| adenosine | weak inhibition | Saccharomyces cerevisiae | |
| Allo-S-Adenosyl-L-methionine | 4 mM inhibits more than 50% | Saccharomyces cerevisiae | |
| dimethyladenosylsulfonium | weak inhibition | Saccharomyces cerevisiae | |
| ethylthioadenosine | 4 mM inhibits more than 50% | Saccharomyces cerevisiae | |
| L-methionine | weak inhibition | Saccharomyces cerevisiae | |
| methionine methylsulfonium | weak inhibition | Saccharomyces cerevisiae | |
| methylthioadenosine | 4 mM inhibits more than 50% | Saccharomyces cerevisiae | |
| Methylthioinosine | weak inhibition | Saccharomyces cerevisiae | |
| S-adenosyl-L-ethionine | 4 mM inhibits more than 50% | Saccharomyces cerevisiae | |
| S-adenosyl-L-homocysteine | 4 mM inhibits 25-50% | Saccharomyces cerevisiae | |
| S-Ribosylmethionine | weak inhibition | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | Saccharomyces cerevisiae | - |
5'-methylthioadenosine + alpha-amino-gamma-butyrolactone | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial purification by a method that includes precipitation with acetone, differential heat inactivation and precipitation by ammonium sulfate | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | 5'-methylthioadenosine + 2-aminobutan-4-olide | - |
ir | |
| S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | 5'-methylthioadenosine + alpha-amino-gamma-butyrolactone | - |
ir | |
| S-adenosylethionine | - |
Saccharomyces cerevisiae | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no cofactor is required | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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