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Literature summary for 2.5.1.39 extracted from
- Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ (2004), Biochem. J., 382, 519-526.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene COQ2, complementation of yeast Coq2 null mutant cells | Saccharomyces cerevisiae |
| gene COQ2, DNA and amino acid sequence determination and analysis, functional expression in and complementation of yeast Coq2 null mutant cells, CoQ biosynthesis rate is lower in the yeast cells when rescued with the human enzyme compared to cells rescued with the yeast enzyme | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | CoQ biosynthesis in yeast null mutant cells can be rescued with expression of the human enzyme at a lower rate compared to cells rescued with the yeast enzyme | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | the enzyme contains 6 transmembrane sequences | Homo sapiens | 16020 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| decaprenyl diphosphate + 4-hydroxybenzoate | Saccharomyces cerevisiae | - |
diphosphate + decaprenyl-4-hydroxybenzoate | - |
? |  |
| decaprenyl diphosphate + 4-hydroxybenzoate | Homo sapiens | - |
diphosphate + decaprenyl-4-hydroxybenzoate | - |
? | |
| additional information | Saccharomyces cerevisiae | the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone | ? | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | Saccharomyces cerevisiae | - |
diphosphate + nonaprenyl-4-hydroxybenzoate | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | Homo sapiens | - |
diphosphate + nonaprenyl-4-hydroxybenzoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q96H96 | - |
- |
| Saccharomyces cerevisiae | - |
gene COQ2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | high enzyme expression | Homo sapiens | - |
| brain | fetal | Homo sapiens | - |
| heart | high enzyme expression | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| skeletal muscle | high enzyme expression | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in recombinant yeast cells | Saccharomyces cerevisiae |
| additional information | - |
activity in recombinant yeast cells | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| decaprenyl diphosphate + 4-hydroxybenzoate | - |
Saccharomyces cerevisiae | diphosphate + decaprenyl-4-hydroxybenzoate | - |
? | |
| decaprenyl diphosphate + 4-hydroxybenzoate | - |
Homo sapiens | diphosphate + decaprenyl-4-hydroxybenzoate | - |
? | |
| decaprenyl diphosphate + 4-hydroxybenzoate | preferred substrate | Homo sapiens | diphosphate + decaprenyl-4-hydroxybenzoate | - |
? | |
| additional information | the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone | Homo sapiens | ? | - |
? | |
| additional information | the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group | Homo sapiens | ? | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | - |
Saccharomyces cerevisiae | diphosphate + nonaprenyl-4-hydroxybenzoate | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | - |
Homo sapiens | diphosphate + nonaprenyl-4-hydroxybenzoate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the enzyme contains 6 transmembrane sequences and an UbiA domain | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COQ2 | - |
Homo sapiens |
| p-hydroxybenzoate:polyprenyl transferase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Saccharomyces cerevisiae |
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Saccharomyces cerevisiae |
| 7.4 | - |
assay at | Homo sapiens |
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