Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the inhibitors tested show antimicrobial, cytotoxic, and enzyme inhibitory activities, overview | Staphylococcus aureus | |
spirohexaline | the molecule shows weak inhibitory activity against catalytically related enzymes such as bacterial octaprenyl pyrophosphate synthase and yeast dehydrodolichyl pyrophosphate synthase, indicating that the compound preferentially inhibits UPP synthase. The inhibitor shows antimicrobial activity, particularly against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), via inhibition of the UPP synthase activity. Molecular docking and homology modeling of UPP synthase-spirohexaline complex | Staphylococcus aureus | |
viridicatumtoxin | originally isolated from Penicillium viridicatum, the molecule shows weak inhibitory activity against catalytically related enzymes such as bacterial octaprenyl pyrophosphate synthase and yeast dehydrodolichyl pyrophosphate synthase, indicating that the compound preferentially inhibits UPP synthase. The inhibitor shows antimicrobial activity, particularly against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Molecular modeling strongly suggests that the hydrophobic spirobicyclic ring of viridicatumtoxin interacts with three hydrophobic clefts of the active site in MRSA UPP synthase | Staphylococcus aureus | |
viridicatumtoxin B | the inhibitor shows antimicrobial activity, particularly against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), via inhibition of the UPP synthase activity | Staphylococcus aureus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Staphylococcus aureus | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | Staphylococcus aureus MRSA252 | - |
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
additional information | Staphylococcus aureus | the precursor for C55-P, undecaprenyl diphosphate (UPP), is synthesized by the addition of eight C5 isopentenyl units (cis[Z]-configuration) onto C15-PP (all-trans [E])-farnesyl diphosphate (FPP) catalyzed by UPP synthase | ? | - |
? | |
additional information | Staphylococcus aureus MRSA252 | the precursor for C55-P, undecaprenyl diphosphate (UPP), is synthesized by the addition of eight C5 isopentenyl units (cis[Z]-configuration) onto C15-PP (all-trans [E])-farnesyl diphosphate (FPP) catalyzed by UPP synthase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | Q6GHH5 | strains ATCC6538p (MSSA) and K24 (MRSA) | - |
Staphylococcus aureus MRSA252 | Q6GHH5 | strains ATCC6538p (MSSA) and K24 (MRSA) | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Staphylococcus aureus | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Staphylococcus aureus MRSA252 | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
additional information | the precursor for C55-P, undecaprenyl diphosphate (UPP), is synthesized by the addition of eight C5 isopentenyl units (cis[Z]-configuration) onto C15-PP (all-trans [E])-farnesyl diphosphate (FPP) catalyzed by UPP synthase | Staphylococcus aureus | ? | - |
? | |
additional information | the precursor for C55-P, undecaprenyl diphosphate (UPP), is synthesized by the addition of eight C5 isopentenyl units (cis[Z]-configuration) onto C15-PP (all-trans [E])-farnesyl diphosphate (FPP) catalyzed by UPP synthase | Staphylococcus aureus MRSA252 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
di-trans-poly-cis-decaprenyl cistransferase | - |
Staphylococcus aureus |
undecaprenyl pyrophosphate synthase | - |
Staphylococcus aureus |
UPP synthase | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.004 | - |
pH 7.5, 37°C | Staphylococcus aureus | viridicatumtoxin | |
0.009 | - |
pH 7.5, 37°C | Staphylococcus aureus | spirohexaline |
General Information | Comment | Organism |
---|---|---|
additional information | molecular docking and homology modeling of UPP synthase | Staphylococcus aureus |