Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Micrococcus luteus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate | mixed inhibition with farnesyl diphosphate, competitive inhibition with reaction intermediate (2Z,6E,10E)-geranylgeranyl diphosphate | Micrococcus luteus | |
3-desmethyl farnesyl diphosphate | competitive with farnesyl diphosphate, mixed inhibition with reaction intermediate (2Z,6E,10E)-geranylgeranyl diphosphate; competitive with farnesyl diphosphate, mixed inhibition with reaction intermediate (Z,E,E)-geranylgeranyl diphosphate | Micrococcus luteus | |
3-desmethyl Z-geranylgeranyl diphosphate | mixed inhibition with farnesyl diphosphate, competitive inhibition with reaction intermediate (Z,E,E)-geranylgeranyl diphosphate | Micrococcus luteus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Micrococcus luteus | - |
- |
- |
Micrococcus luteus | - |
B-P 26 | - |
Micrococcus luteus B-P 26 | - |
- |
- |
Micrococcus luteus B-P 26 | - |
B-P 26 | - |
Purification (Comment) | Organism |
---|---|
- |
Micrococcus luteus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Micrococcus luteus | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Micrococcus luteus B-P 26 | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
(2Z,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate | - |
Micrococcus luteus | ? | - |
? | |
(2Z,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate | - |
Micrococcus luteus B-P 26 | ? | - |
? | |
additional information | artificial substrate analogs, 3-desmethyl farnesyl diphosphate and 3-desmethyl Z-geranylgeranyl diphosphate are not used as substrates. The methyl group at the 3-position of the allylic substrate is important in the undecaprenyl diphosphate synthase reaction. The binding sites for the natural substrate farnesyl diphosphate and those for the intermediate allylic diphosphate, which contains the cis-prenyl unit, are different during the cis-prenyl chain elongation reaction | Micrococcus luteus | ? | - |
? | |
additional information | artificial substrate analogs, 3-desmethyl farnesyl diphosphate and 3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate are not used as substrates. The methyl group at the 3-position of the allylic substrate is important in the undecaprenyl diphosphate synthase reaction. The binding sites for the natural substrate farnesyl diphosphate and those for the intermediate allylic diphosphate, which contains the cis-prenyl unit, are different during the cis-prenyl chain elongation reaction | Micrococcus luteus | ? | - |
? | |
additional information | artificial substrate analogs, 3-desmethyl farnesyl diphosphate and 3-desmethyl Z-geranylgeranyl diphosphate are not used as substrates. The methyl group at the 3-position of the allylic substrate is important in the undecaprenyl diphosphate synthase reaction. The binding sites for the natural substrate farnesyl diphosphate and those for the intermediate allylic diphosphate, which contains the cis-prenyl unit, are different during the cis-prenyl chain elongation reaction | Micrococcus luteus B-P 26 | ? | - |
? | |
additional information | artificial substrate analogs, 3-desmethyl farnesyl diphosphate and 3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate are not used as substrates. The methyl group at the 3-position of the allylic substrate is important in the undecaprenyl diphosphate synthase reaction. The binding sites for the natural substrate farnesyl diphosphate and those for the intermediate allylic diphosphate, which contains the cis-prenyl unit, are different during the cis-prenyl chain elongation reaction | Micrococcus luteus B-P 26 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
undecaprenyl diphosphate synthase | - |
Micrococcus luteus |
UPP synthase | - |
Micrococcus luteus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Micrococcus luteus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Micrococcus luteus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
3-desmethyl Z-geranylgeranyl diphosphate | substrate farnesyl diphosphate, pH 7.5, 37°C | Micrococcus luteus | |
0.017 | - |
3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate | substrate farnesyl diphosphate, pH 7.5, 37°C | Micrococcus luteus | |
0.028 | - |
3-desmethyl Z-geranylgeranyl diphosphate | substrate (Z,E,E)-geranylgeranyl diphosphate, pH 7.5, 37°C | Micrococcus luteus | |
0.028 | - |
3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate | substrate (Z,E,E)-geranylgeranyl diphosphate, pH 7.5, 37°C | Micrococcus luteus | |
0.045 | - |
3-desmethyl farnesyl diphosphate | substrate farnesyl diphosphate, pH 7.5, 37°C | Micrococcus luteus | |
2.8 | - |
3-desmethyl farnesyl diphosphate | substrate (Z,E,E)-geranylgeranyl diphosphate, pH 7.5, 37°C | Micrococcus luteus | |
2.8 | - |
3-desmethyl farnesyl diphosphate | substrate (2Z,6E,10E)-geranylgeranyl diphosphate, pH 7.5, 37°C | Micrococcus luteus |