Application | Comment | Organism |
---|---|---|
pharmacology | geranylgeranyl diphosphate is a key precursor for taxol, one of the most potent antitumor drugs | Taxus x media |
Cloned (Comment) | Organism |
---|---|
expression in yeast mutant lacking GGPPS activity, the geranylgeranyl diphosphate synthase is free of introns | Taxus x media |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(E,E)-farnesyl diphosphate + isopentenyl diphosphate | Taxus x media | inducible by methyl jasmonate. The product geranylgeranyl diphosphate is a key precursor for diterpenes and, in particular, Taxol, one of the most potent antitumor drugs | diphosphate + geranylgeranyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taxus x media | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(E,E)-farnesyl diphosphate + isopentenyl diphosphate | inducible by methyl jasmonate. The product geranylgeranyl diphosphate is a key precursor for diterpenes and, in particular, Taxol, one of the most potent antitumor drugs | Taxus x media | diphosphate + geranylgeranyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
geranylgeranyl diphosphate synthase | - |
Taxus x media |
GGPPS | - |
Taxus x media |