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Literature summary for 2.5.1.29 extracted from

  • Liao, Z.; Gong, Y.; Kai, G.; Zuo, K.; Chen, M.; Tan, Q.; Wei, Y.; Guo, L.; Tan, F.; Sun, X.; Tang, K.
    An intron-free methyl jasmonate inducible geranylgeranyl diphosphate synthase gene from Taxus media and its functional identification in yeast (2005), Mol. Biol., 39, 11-17.
No PubMed abstract available

Application

Application Comment Organism
pharmacology geranylgeranyl diphosphate is a key precursor for taxol, one of the most potent antitumor drugs Taxus x media

Cloned(Commentary)

Cloned (Comment) Organism
expression in yeast mutant lacking GGPPS activity, the geranylgeranyl diphosphate synthase is free of introns Taxus x media

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E,E)-farnesyl diphosphate + isopentenyl diphosphate Taxus x media inducible by methyl jasmonate. The product geranylgeranyl diphosphate is a key precursor for diterpenes and, in particular, Taxol, one of the most potent antitumor drugs diphosphate + geranylgeranyl diphosphate
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?

Organism

Organism UniProt Comment Textmining
Taxus x media
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E,E)-farnesyl diphosphate + isopentenyl diphosphate inducible by methyl jasmonate. The product geranylgeranyl diphosphate is a key precursor for diterpenes and, in particular, Taxol, one of the most potent antitumor drugs Taxus x media diphosphate + geranylgeranyl diphosphate
-
?

Synonyms

Synonyms Comment Organism
geranylgeranyl diphosphate synthase
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Taxus x media
GGPPS
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Taxus x media