Cloned (Comment) | Organism |
---|---|
protein expressed from 1a-type mRNA is active, protein expressed from 1b-type mRNA is inactive, expression level in HeLa cells, Cos-7 and 293 cells is about 10% relative to that in Escherichia coli. When fusion of beta-galactosidase with C-terminal regions differing between the 1a-type and the 1b-type proteins are expressed in HeLa cells, the expressed fusion proteins are both active but the latter fusion protein expresion level is considerably low compared with the former one | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(E,E)-farnesyl diphosphate + isopentenyl diphosphate | Rattus norvegicus | the expression level of the active GGPS is at least regulated through the splicing of intron 4b of its gene | diphosphate + geranylgeranyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q6F596 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form | Rattus norvegicus | - |
heart | expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form | Rattus norvegicus | - |
liver | expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form | Rattus norvegicus | - |
ovary | expression level of 1a-type mRNA, encoding the active enzyme form is the same as that of 1b-type mRNA, encoding an inactive enzyme form. During testis development the total GGPS mRNSA expression level increases, accompanied by an increase in 1 n-type mRNA, the expression level pf 1a-type mRNA remains kept unchanges | Rattus norvegicus | - |
testis | expression level of 1a-type mRNA, encoding the active enzyme form is the same as that of 1b-type mRNA, encoding an inactive enzyme form | Rattus norvegicus | - |
thymus | expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(E,E)-farnesyl diphosphate + isopentenyl diphosphate | - |
Rattus norvegicus | diphosphate + geranylgeranyl diphosphate | - |
? | |
(E,E)-farnesyl diphosphate + isopentenyl diphosphate | the expression level of the active GGPS is at least regulated through the splicing of intron 4b of its gene | Rattus norvegicus | diphosphate + geranylgeranyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
geranylgeranyl diphosphate synthase | - |
Rattus norvegicus |
GGPS | - |
Rattus norvegicus |