Literature summary for 2.5.1.21 extracted from

Thompson, J.F.; Danley, D.E.; Mazzalupo, S.; Milos, P.M.; Lira, M.E.; Harwood, H.J., Jr.
Truncation of human squalene synthase yields active, crystallizable protein (1998), Arch. Biochem. Biophys., 350, 283-290.

Search for more literature for 2.5.1.21

Crystallization (Commentary)

Crystallization (Comment)	Organism
mutant with deletion of 47 C-terminal amino acids	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of 30 N-terminal amino acids without effect to activity, additional deletion of 81 to 97 C-terminal amino acids abolishes activity, deletion of only 47 C-terminal amino acids retains activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
CP-294838	a benzoxazepinone IC50 130 nM	Homo sapiens
CP-295697	a bisphosphonate, IC50: 20 nM	Homo sapiens
zaragozic acid	IC50 0.7 nM	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0023	-	farnesyl diphosphate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P37268	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + farnesyl diphosphate	-	Homo sapiens	diphosphate + presqualene diphosphate	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000007	-	IC50 0.7 nM	Homo sapiens	zaragozic acid
0.00002	-	a bisphosphonate, IC50: 20 nM	Homo sapiens	CP-295697
0.00013	-	a benzoxazepinone IC50 130 nM	Homo sapiens	CP-294838

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Release 2023.1 (January 2023)