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Literature summary for 2.5.1.2 extracted from

  • Lau, S.; Lam, C.; Curreem, S.; Lee, K.; Chow, W.; Lau, C.; Sridhar, S.; Wong, S.; Martelli, P.; Hui, S.; Yuen, K.; Woo, P.
    Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway (2015), Cell Biosci., 5, 26.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Burkholderia pseudomallei
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Burkholderia thailandensis
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Synonyms

Synonyms Comment Organism
thiaminase I
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Burkholderia pseudomallei
thiaminase I
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Burkholderia thailandensis

General Information

General Information Comment Organism
physiological function Burkholderia pseudomallei possesses thiaminase I which catalyzes degradation of thiamine to 4-methyl-5-thiazoleethanol. ThiM, which encodes hydroxyethylthiazole kinase responsible for degradation of 4-methyl-5-thiazoleethanol, is absent or not expressed in all Burkholderia pseudomallei strains. The high 4-methyl-5-thiazoleethanol level in Burkholderia pseudomallei is likely due to the absence of hydroxyethylthiazole kinase and hence reduced downstream degradation Burkholderia pseudomallei
physiological function Burkholderia thailandensis possesses thiaminase I which catalyzes degradation of thiamine to 4-methyl-5-thiazoleethanol. ThiM, which encodes hydroxyethylthiazole kinase responsible for degradation of 4-methyl-5-thiazoleethanol, is present and expressed in Burkholderia thailandensis Burkholderia thailandensis