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Literature summary for 2.5.1.2 extracted from
- Reversible inactivation of cellular thiaminase I in Bacillus thiaminolyticus by thiamine and heteropyrithiamine (1972), J. Biochem., 72, 1053-1055.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Heteropyrithiamine | inhibitory at 0.006 mM | Paenibacillus thiaminolyticus |  |
| additional information | chloramphenicol does not affect activity suggesting that the enzyme has an inactive form | Paenibacillus thiaminolyticus | |
| thiamine | reversible inactivation above 0.0003 mM | Paenibacillus thiaminolyticus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell associated | - |
Paenibacillus thiaminolyticus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paenibacillus thiaminolyticus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Paenibacillus thiaminolyticus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiamine + pyridine | - |
Paenibacillus thiaminolyticus | heteropyrithiamine + 4-methyl-5-(2-hydroxyethyl)-thiazole | - |
? | |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
after dialysis, 60 min of incubation restore 90% of activity inhibited by thiamine | Paenibacillus thiaminolyticus |
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Release 2023.1 (January 2023)
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