Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.17 extracted from

  • Fonseca, M.V.; Buan, N.R.; Horswill, A.R.; Rayment, I.; Escalante-Semerena, J.C.
    The ATP:co(I)rrinoid adenosyltransferase (CobA) enzyme of Salmonella enterica requires the 2'-OH group of ATP for function and yields inorganic triphosphate as its reaction byproduct (2002), J. Biol. Chem., 277, 33127-33131.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5'-mercapto-5'-deoxyadenosine-5'-triphosphate complete inhibition at a 3 mM concentration Salmonella enterica
additional information alpha,beta-methylene-substituted derivatives of ATP are poor inhibitors Salmonella enterica
Triphosphate
-
Salmonella enterica

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Salmonella enterica

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
serovar typhimurium
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cob(I)alamin
-
Salmonella enterica triphosphate + coenzyme B12 adenosylcobalamin, B12-coenzyme or deoxyadenosyl-B12 ?
additional information crucial role of the 2'-OH group of the ribosyl moiety of ATP, the gamma-phosphate of ATP is critical for positioning the target for nucleophilic attack, differences in the base of the nucleotide have no effect on enzyme activity, 2'-deoxynucleotides fails to serve as substrates Salmonella enterica ?
-
?