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Literature summary for 2.5.1.15 extracted from
- 7,8-Dihydropteroate-synthesizing enzyme from Plasmodium chabaudi (1980), Methods Enzymol., 66, 564-570.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Sulfaguanidine | - |
Plasmodium chabaudi |  |
| sulfanilamide | - |
Plasmodium chabaudi | |
| sulfathiazole | competitive to 4-aminobenzoate | Plasmodium chabaudi | |
| sulfonamide | competitive to 4-aminobenzoate | Plasmodium chabaudi | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
4-Aminobenzoate | - |
Plasmodium chabaudi | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 190000 | - |
Sephadex chromatography | Plasmodium chabaudi |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | Plasmodium chabaudi | - |
diphosphate + 7,8-dihydropteroate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium chabaudi | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| precipitation with ammonium sulfate followed by column chromatography | Plasmodium chabaudi |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Plasmodium chabaudi | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 15.78 | - |
- |
Plasmodium chabaudi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Plasmodium chabaudi | diphosphate + 7,8-dihydropteroate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Plasmodium chabaudi |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | 9 | - |
Plasmodium chabaudi |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.014 | - |
sulfathiazole | - |
Plasmodium chabaudi | |
| 0.069 | - |
Sulfaguanidine | - |
Plasmodium chabaudi | |
| 0.13 | - |
sulfanilamide | - |
Plasmodium chabaudi | |
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