Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Aspergillus fumigatus |
Protein Variants | Comment | Organism |
---|---|---|
G115A | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
G115A/Y205C | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
Y205C | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
Y205F | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
Y205I | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
Y205L | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
Y205M | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
Y205S | significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme | Aspergillus fumigatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
brevianamide F + dimethylallyl diphosphate | Aspergillus fumigatus | - |
diphosphate + tryprostatin B | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Aspergillus fumigatus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,6-dihydroxynaphthalene + dimethylallyl diphosphate | mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 | Aspergillus fumigatus | diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalene-1,6-diol | - |
? | |
1,7-dihydroxynaphthalene + dimethylallyl diphosphate | mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 | Aspergillus fumigatus | diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalene-1,7-diol | - |
? | |
1-amino-7-hydroxynaphthalene + dimethylallyl diphosphate | mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 | Aspergillus fumigatus | diphosphate + 8-amino-7-(3-methylbut-2-en-1-yl)naphthalen-2-ol | - |
? | |
1-naphthol + dimethylallyl diphosphate | mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 | Aspergillus fumigatus | diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalen-1-ol | - |
? | |
2,3-dihydroxynaphthalene + dimethylallyl diphosphate | mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 | Aspergillus fumigatus | diphosphate + ? | - |
? | |
2-naphthol + dimethylallyl diphosphate | mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 | Aspergillus fumigatus | diphosphate + ? | - |
? | |
brevianamide F + dimethylallyl diphosphate | - |
Aspergillus fumigatus | diphosphate + tryprostatin B | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cyclic dipeptide C2-prenyltransferase FtmPT1 | - |
Aspergillus fumigatus |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the biosynthesis of a number of biologically active natural products including tryprostatins, spirotryprostatins, verruculogen, and fumitremorgins | Aspergillus fumigatus |