Literature summary for 2.5.1.10 extracted from

Marzinzik, A.L.; Amstutz, R.; Bold, G.; Bourgier, E.; Cotesta, S.; Glickman, J.F.; Goette, M.; Henry, C.; Lehmann, S.; Hartwieg, J.C.; Ofner, S.; Pelle, X.; Roddy, T.P.; Rondeau, J.M.; Stauffer, F.; Stout, S.J.; Widmer, A.; Zimmermann, J.; Zoller, T.; Jahnke, W.
Discovery of novel allosteric non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase by integrated lead finding (2015), ChemMedChem, 10, 1884-1891.

Inhibitors

Inhibitors	Comment	Organism
1-[(3-carboxy-1,2-oxazol-5-yl)methyl]-1H-benzo[g]indole-2-carboxylic acid	-	Homo sapiens
1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid	-	Homo sapiens
1H,1'H-4,4'-biindole-2-carboxylic acid	-	Homo sapiens
2-(naphthalen-1-ylmethoxy)-4-(phenylamino)benzoic acid	-	Homo sapiens
2-(naphthalen-1-ylmethoxy)benzoic acid	-	Homo sapiens
3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid	-	Homo sapiens
4'-(hydroxymethyl)-3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid	-	Homo sapiens
4'-(methylcarbamoyl)-3-[(naphthalen-1-yl)methoxy][1,1'-biphenyl]-4-carboxylic acid	-	Homo sapiens
4'-acetamido-3-[(naphthalen-1-yl)methoxy][1,1'-biphenyl]-4-carboxylic acid	-	Homo sapiens
4'-carbamoyl-3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid	-	Homo sapiens
4'-fluoro-3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid	-	Homo sapiens
4'-[(methanesulfonyl)amino]-3-[(naphthalen-1-yl)methoxy][1,1'-biphenyl]-4-carboxylic acid	-	Homo sapiens
4-(1,3-benzodioxol-5-yl)-2-(naphthalen-1-ylmethoxy)benzoic acid	-	Homo sapiens
4-(1-methyl-1H-indol-5-yl)-2-[(naphthalen-1-yl)methoxy]benzoic acid	-	Homo sapiens
4-(1H-indol-5-yl)-2-(naphthalen-1-ylmethoxy)benzoic acid	-	Homo sapiens
4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(naphthalen-1-yl)methoxy]benzoic acid	-	Homo sapiens
4-(6-methoxynaphthalen-2-yl)-2-[(naphthalen-1-yl)methoxy]benzoic acid	-	Homo sapiens
4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid	-	Homo sapiens
6-amino-5-ethoxy-8-(naphthalen-1-yl)quinoline-2-carboxylic acid	-	Homo sapiens
6-amino-8-(naphthalen-1-yl)quinoline-2-carboxylic acid	-	Homo sapiens
6-[(ethoxycarbonyl)amino]-8-(naphthalen-1-yl)quinoline-2-carboxylic acid	-	Homo sapiens
8-(1H-indol-4-yl)quinoline-2-carboxylic acid	-	Homo sapiens
8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid	-	Homo sapiens
8-(naphthalen-1-yl)-6-(thiophen-3-yl)quinoline-2-carboxylic acid	-	Homo sapiens
8-(naphthalen-1-yl)quinoline-2-carboxylic acid	-	Homo sapiens
zoledronic acid	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
geranyl diphosphate + isopentenyl diphosphate	Homo sapiens	-	diphosphate + (2E,6E)-farnesyl diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranyl diphosphate + isopentenyl diphosphate	-	Homo sapiens	diphosphate + (2E,6E)-farnesyl diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
farnesyl pyrophosphate synthase	-	Homo sapiens
FPPS	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000017	-	pH and temperature not specified in the publication	Homo sapiens	4'-acetamido-3-[(naphthalen-1-yl)methoxy][1,1'-biphenyl]-4-carboxylic acid
0.000024	-	pH and temperature not specified in the publication	Homo sapiens	6-amino-5-ethoxy-8-(naphthalen-1-yl)quinoline-2-carboxylic acid
0.000037	-	pH and temperature not specified in the publication	Homo sapiens	6-[(ethoxycarbonyl)amino]-8-(naphthalen-1-yl)quinoline-2-carboxylic acid
0.000038	-	pH and temperature not specified in the publication	Homo sapiens	4-(6-methoxynaphthalen-2-yl)-2-[(naphthalen-1-yl)methoxy]benzoic acid
0.000049	-	pH and temperature not specified in the publication	Homo sapiens	4-(1,3-benzodioxol-5-yl)-2-(naphthalen-1-ylmethoxy)benzoic acid
0.000058	-	pH and temperature not specified in the publication	Homo sapiens	4'-(hydroxymethyl)-3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid
0.000069	-	pH and temperature not specified in the publication	Homo sapiens	6-amino-8-(naphthalen-1-yl)quinoline-2-carboxylic acid
0.000077	-	pH and temperature not specified in the publication	Homo sapiens	8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid
0.00008	-	pH and temperature not specified in the publication	Homo sapiens	4'-fluoro-3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid
0.0001	-	pH and temperature not specified in the publication	Homo sapiens	8-(naphthalen-1-yl)-6-(thiophen-3-yl)quinoline-2-carboxylic acid
0.00011	-	pH and temperature not specified in the publication	Homo sapiens	4'-carbamoyl-3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid
0.00014	-	pH and temperature not specified in the publication	Homo sapiens	4'-(methylcarbamoyl)-3-[(naphthalen-1-yl)methoxy][1,1'-biphenyl]-4-carboxylic acid
0.00019	-	pH and temperature not specified in the publication	Homo sapiens	4-(1H-indol-5-yl)-2-(naphthalen-1-ylmethoxy)benzoic acid
0.00025	-	pH and temperature not specified in the publication	Homo sapiens	4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(naphthalen-1-yl)methoxy]benzoic acid
0.00027	-	pH and temperature not specified in the publication	Homo sapiens	4-(1-methyl-1H-indol-5-yl)-2-[(naphthalen-1-yl)methoxy]benzoic acid
0.00085	-	pH and temperature not specified in the publication	Homo sapiens	3-(naphthalen-1-ylmethoxy)biphenyl-4-carboxylic acid
0.0012	-	pH and temperature not specified in the publication	Homo sapiens	8-(naphthalen-1-yl)quinoline-2-carboxylic acid
0.00123	-	pH and temperature not specified in the publication	Homo sapiens	4'-[(methanesulfonyl)amino]-3-[(naphthalen-1-yl)methoxy][1,1'-biphenyl]-4-carboxylic acid
0.0068	-	pH and temperature not specified in the publication	Homo sapiens	2-(naphthalen-1-ylmethoxy)benzoic acid
0.0071	-	pH and temperature not specified in the publication	Homo sapiens	4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid
0.0139	-	pH and temperature not specified in the publication	Homo sapiens	1H,1'H-4,4'-biindole-2-carboxylic acid
0.02	-	pH and temperature not specified in the publication	Homo sapiens	2-(naphthalen-1-ylmethoxy)-4-(phenylamino)benzoic acid
0.02	-	pH and temperature not specified in the publication	Homo sapiens	8-(1H-indol-4-yl)quinoline-2-carboxylic acid