Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a target for Chagas disease chemotherapy | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[(benzylamino)ethyl] 1,1-bisphosphonic acid | - |
Toxoplasma gondii | |
1-[(benzylamino)ethyl] 1,1-bisphosphonic acid | - |
Trypanosoma cruzi | |
1-[(n-dec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Toxoplasma gondii | |
1-[(n-dec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Trypanosoma cruzi | |
1-[(n-dodec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Toxoplasma gondii | |
1-[(n-dodec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Trypanosoma cruzi | |
1-[(n-non-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Toxoplasma gondii | |
1-[(n-non-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Trypanosoma cruzi | |
1-[(n-tetradec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Toxoplasma gondii | |
1-[(n-tetradec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Trypanosoma cruzi | |
1-[(n-undec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Toxoplasma gondii | |
1-[(n-undec-1-ylamino)ethyl] 1,1-bisphosphonic acid | - |
Trypanosoma cruzi | |
alendronate | - |
Toxoplasma gondii | |
alendronate | - |
Trypanosoma cruzi | |
ibandronate | - |
Toxoplasma gondii | |
ibandronate | - |
Trypanosoma cruzi | |
pamidronate | - |
Toxoplasma gondii | |
pamidronate | - |
Trypanosoma cruzi | |
risedronate | - |
Toxoplasma gondii | |
risedronate | - |
Trypanosoma cruzi | |
[2-(heptylamino)ethane-1,1-diyl]bis(phosphonic acid) | - |
Toxoplasma gondii | |
[2-(heptylamino)ethane-1,1-diyl]bis(phosphonic acid) | - |
Trypanosoma cruzi | |
[2-(hexylamino)ethane-1,1-diyl]bis(phosphonic acid) | competitive inhibitor | Toxoplasma gondii | |
[2-(hexylamino)ethane-1,1-diyl]bis(phosphonic acid) | competitive inhibitor | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | Q197X6 | - |
- |
Trypanosoma cruzi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Trypanosoma cruzi | - |
tachyzoite | - |
Toxoplasma gondii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranyl diphosphate + isopentenyl diphosphate | - |
Trypanosoma cruzi | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | - |
Toxoplasma gondii | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
farnesyl diphosphate synthase | - |
Trypanosoma cruzi |
farnesyl diphosphate synthase | - |
Toxoplasma gondii |
FPPS | - |
Trypanosoma cruzi |
FPPS | - |
Toxoplasma gondii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000027 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | risedronate | |
0.000058 | - |
pH and temperature not specified in the publication | Trypanosoma cruzi | [2-(heptylamino)ethane-1,1-diyl]bis(phosphonic acid) | |
0.000068 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Toxoplasma gondii | 1-[(n-dec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.000074 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Toxoplasma gondii | risedronate | |
0.000093 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Toxoplasma gondii | 1-[(n-dodec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.00014 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | [2-(hexylamino)ethane-1,1-diyl]bis(phosphonic acid) | |
0.000292 | - |
IC50 above 0.001 mM, in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Toxoplasma gondii | 1-[(n-tetradec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.00043 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | 1-[(n-non-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.00044 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Toxoplasma gondii | 1-[(n-non-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.000811 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | 1-[(n-dodec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.000856 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | 1-[(n-undec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.000868 | - |
in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Toxoplasma gondii | 1-[(n-undec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.001 | - |
IC50 above 0.001 mM, in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | 1-[(n-dec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.001 | - |
IC50 above 0.001 mM, in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | 1-[(n-tetradec-1-ylamino)ethyl] 1,1-bisphosphonic acid | |
0.001 | - |
IC50 above 0.001 mM, in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 2 mM dithiothreitol, at 37°C | Trypanosoma cruzi | 1-[(benzylamino)ethyl] 1,1-bisphosphonic acid | |
0.00135 | - |
pH and temperature not specified in the publication | Trypanosoma cruzi | [2-(hexylamino)ethane-1,1-diyl]bis(phosphonic acid) |